DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism

DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism

Abstract Background The stability of p53 is mainly controlled by ubiquitin-dependent degradation, which is triggered by the E3 ubiquitin ligase MDM2. The chromatin modifier lymphoid-specific helicase (LSH) is essential for DNA methylation and cancer progression as a transcriptional repressor. The po...

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Bibliographic Details
Main Authors: Ling Chen, Ying Shi, Na Liu, Zuli Wang, Rui Yang, Bin Yan, Xiaoli Liu, Weiwei Lai, Yating Liu, Desheng Xiao, Hu Zhou, Yan Cheng, Ya Cao, Shuang Liu, Zanxian Xia, Yongguang Tao
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Epigenetics & Chromatin
Subjects:
LSH
P53
DUB
PKM2
Lipid metabolism
Online Access:http://link.springer.com/article/10.1186/s13072-019-0302-9

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