Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry
There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several reports describing the synthesis and properties of n...
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MDPI AG
2012-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/11/12665 |
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doaj-3ca12cf31b9145eebe3d4613b50dcace2020-11-24T23:43:36ZengMDPI AGMolecules1420-30492012-10-011711126651270310.3390/molecules171112665Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click ChemistryWei GongTim EfthymiouJean-Paul DesaulniersThere is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several reports describing the synthesis and properties of novel triazole-modified nucleic acid derivatives for potential downstream DNA- and RNA-based applications. This review will focus on highlighting representative novel nucleic acid molecular structures that have been synthesized via the “click” azide-alkyne cycloaddition. Many of these derivatives show compatibility for various applications that involve enzymatic transformation, nucleic acid hybridization, molecular tagging and purification, and gene silencing. The details of these applications are discussed. In conclusion, the future of nucleic acid analogues functionalized with triazoles is promising.http://www.mdpi.com/1420-3049/17/11/12665click chemistrytriazoleCuAACnucleic acidsoligonucleotidesbioconjugationcopper-catalyzedHuisgen dipolar cycloadditionazidealkyne |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wei Gong Tim Efthymiou Jean-Paul Desaulniers |
| spellingShingle |
Wei Gong Tim Efthymiou Jean-Paul Desaulniers Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry Molecules click chemistry triazole CuAAC nucleic acids oligonucleotides bioconjugation copper-catalyzed Huisgen dipolar cycloaddition azide alkyne |
| author_facet |
Wei Gong Tim Efthymiou Jean-Paul Desaulniers |
| author_sort |
Wei Gong |
| title |
Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry |
| title_short |
Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry |
| title_full |
Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry |
| title_fullStr |
Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry |
| title_full_unstemmed |
Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry |
| title_sort |
chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2012-10-01 |
| description |
There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several reports describing the synthesis and properties of novel triazole-modified nucleic acid derivatives for potential downstream DNA- and RNA-based applications. This review will focus on highlighting representative novel nucleic acid molecular structures that have been synthesized via the “click” azide-alkyne cycloaddition. Many of these derivatives show compatibility for various applications that involve enzymatic transformation, nucleic acid hybridization, molecular tagging and purification, and gene silencing. The details of these applications are discussed. In conclusion, the future of nucleic acid analogues functionalized with triazoles is promising. |
| topic |
click chemistry triazole CuAAC nucleic acids oligonucleotides bioconjugation copper-catalyzed Huisgen dipolar cycloaddition azide alkyne |
| url |
http://www.mdpi.com/1420-3049/17/11/12665 |
| work_keys_str_mv |
AT weigong chemicalarchitectureandapplicationsofnucleicacidderivativescontaining123triazolefunctionalitiessynthesizedviaclickchemistry AT timefthymiou chemicalarchitectureandapplicationsofnucleicacidderivativescontaining123triazolefunctionalitiessynthesizedviaclickchemistry AT jeanpauldesaulniers chemicalarchitectureandapplicationsofnucleicacidderivativescontaining123triazolefunctionalitiessynthesizedviaclickchemistry |
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1725501021839425536 |