Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use
Chuan-Jiang Li,1,* Liang Li2,* 1Department of Surgery, Nanfang Hospital, 2Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People’s Republic of China *The authors contributed equally to this work Abstract: Tacro...
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doaj-3caeb40909fc4d4d8e50ce3aef04a68a2020-11-25T00:09:29ZengDove Medical PressDrug Design, Development and Therapy1177-88812015-01-012015default47348519953Tacrolimus in preventing transplant rejection in Chinese patients – optimizing useLi CJLi L Chuan-Jiang Li,1,* Liang Li2,* 1Department of Surgery, Nanfang Hospital, 2Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People’s Republic of China *The authors contributed equally to this work Abstract: Tacrolimus is a product of fermentation of Streptomyces, and belongs to the family of calcineurin inhibitors. It is a widely used immunosuppressive drug for preventing solid-organ transplant rejection. Compared to cyclosporine, tacrolimus has greater immunosuppressive potency and a lower incidence of side effects. It has been accepted as first-line treatment after liver and kidney transplantation. Tacrolimus has specific features in Chinese transplant patients; its in vivo pharmacokinetics, treatment regimen, dose and administration, and adverse-effect profile are influenced by multiple factors, such as genetics and the spectrum of primary diseases in the Chinese population. We reviewed the clinical experience of tacrolimus use in Chinese liver- and kidney-transplant patients, including the pharmacology of tacrolimus, the immunosuppressive effects of tacrolimus versus cyclosporine, effects of different factors on tacrolimus metabolism on Chinese patients, personalized medicine, clinical safety profile, and patient satisfaction and adherence. This article provides guidance for the rational and efficient use of tacrolimus in Chinese organ-transplant patients. Keywords: tacrolimus, liver transplantation, kidney transplant, Chinese, personalized medicinehttp://www.dovepress.com/tacrolimus-in-preventing-transplant-rejection-innbspchinese-patients-n-peer-reviewed-article-DDDT |
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English |
format |
Article |
sources |
DOAJ |
author |
Li CJ Li L |
spellingShingle |
Li CJ Li L Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use Drug Design, Development and Therapy |
author_facet |
Li CJ Li L |
author_sort |
Li CJ |
title |
Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use |
title_short |
Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use |
title_full |
Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use |
title_fullStr |
Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use |
title_full_unstemmed |
Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use |
title_sort |
tacrolimus in preventing transplant rejection in chinese patients – optimizing use |
publisher |
Dove Medical Press |
series |
Drug Design, Development and Therapy |
issn |
1177-8881 |
publishDate |
2015-01-01 |
description |
Chuan-Jiang Li,1,* Liang Li2,* 1Department of Surgery, Nanfang Hospital, 2Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People’s Republic of China *The authors contributed equally to this work Abstract: Tacrolimus is a product of fermentation of Streptomyces, and belongs to the family of calcineurin inhibitors. It is a widely used immunosuppressive drug for preventing solid-organ transplant rejection. Compared to cyclosporine, tacrolimus has greater immunosuppressive potency and a lower incidence of side effects. It has been accepted as first-line treatment after liver and kidney transplantation. Tacrolimus has specific features in Chinese transplant patients; its in vivo pharmacokinetics, treatment regimen, dose and administration, and adverse-effect profile are influenced by multiple factors, such as genetics and the spectrum of primary diseases in the Chinese population. We reviewed the clinical experience of tacrolimus use in Chinese liver- and kidney-transplant patients, including the pharmacology of tacrolimus, the immunosuppressive effects of tacrolimus versus cyclosporine, effects of different factors on tacrolimus metabolism on Chinese patients, personalized medicine, clinical safety profile, and patient satisfaction and adherence. This article provides guidance for the rational and efficient use of tacrolimus in Chinese organ-transplant patients. Keywords: tacrolimus, liver transplantation, kidney transplant, Chinese, personalized medicine |
url |
http://www.dovepress.com/tacrolimus-in-preventing-transplant-rejection-innbspchinese-patients-n-peer-reviewed-article-DDDT |
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