HIV-2 infection: Where are we today?
Context: The choice of antiretroviral therapy for HIV-2 differs from that for HIV-1, underscoring the importance of differentiating between the two. Aims: The current study was planned to find out the prevalence of HIV-2 infection at our center and to find out the utility of the current diagnostic a...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2013-01-01
|
Series: | Journal of Global Infectious Diseases |
Subjects: | |
Online Access: | http://www.jgid.org/article.asp?issn=0974-777X;year=2013;volume=5;issue=3;spage=110;epage=113;aulast=Ingole |
id |
doaj-3cc2d3dc4a3b4fb3b4bef3d25f010bae |
---|---|
record_format |
Article |
spelling |
doaj-3cc2d3dc4a3b4fb3b4bef3d25f010bae2020-11-24T22:40:43ZengWolters Kluwer Medknow PublicationsJournal of Global Infectious Diseases0974-777X2013-01-015311011310.4103/0974-777X.116872HIV-2 infection: Where are we today?Nayana A IngolePurva P SarkateSupriya M ParanjpeSameer D ShindeSujata S LallPreeti R MehtaContext: The choice of antiretroviral therapy for HIV-2 differs from that for HIV-1, underscoring the importance of differentiating between the two. Aims: The current study was planned to find out the prevalence of HIV-2 infection at our center and to find out the utility of the current diagnostic algorithm in identifying the type of HIV infection. Setting and Design: Retrospective analysis in a tertiary care teaching institute over a period of three years. Materials and Methods: All patients diagnosed as HIV infected using NACO/WHO HIV testing strategy III were included in the study. They were classified as HIV-1 infected, HIV-2 infected and HIV-1 and HIV-2 co-infected based on their test results. For discordant samples, immunoblotting result from National Reference Laboratory was considered as final. Statistical Analysis Used: Comparison between HIV-1, HIV-2 and HIV-1+2 positive groups for age, gender, route of transmission was made using chi squared test. P value < 0.05 was considered as significant. Results: Of the total of 66,708 patients tested, 5,238 (7.9%) were positive for HIV antibodies. 7.62%, 0.14%, 0.08% and 0.004% were HIV-1, HIV-2, HIV-1 and HIV-2 co-infected and HIV type indeterminate (HIV-1 Indeterminate, 2+) respectively. The current algorithm could not differentiate between the types of HIV infection (as HIV-1 or HIV-2) in 63 (1.2%) cases. Conclusion: In areas like the Indian subcontinent, where epidemic of both HIV-1 and HIV-2 infections are ongoing, it is important to modify the current diagnostic algorithms to diagnose and confirm HIV-2 infections.http://www.jgid.org/article.asp?issn=0974-777X;year=2013;volume=5;issue=3;spage=110;epage=113;aulast=IngoleHIVHIV epidemicHIV-2Testing algorithm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nayana A Ingole Purva P Sarkate Supriya M Paranjpe Sameer D Shinde Sujata S Lall Preeti R Mehta |
spellingShingle |
Nayana A Ingole Purva P Sarkate Supriya M Paranjpe Sameer D Shinde Sujata S Lall Preeti R Mehta HIV-2 infection: Where are we today? Journal of Global Infectious Diseases HIV HIV epidemic HIV-2 Testing algorithm |
author_facet |
Nayana A Ingole Purva P Sarkate Supriya M Paranjpe Sameer D Shinde Sujata S Lall Preeti R Mehta |
author_sort |
Nayana A Ingole |
title |
HIV-2 infection: Where are we today? |
title_short |
HIV-2 infection: Where are we today? |
title_full |
HIV-2 infection: Where are we today? |
title_fullStr |
HIV-2 infection: Where are we today? |
title_full_unstemmed |
HIV-2 infection: Where are we today? |
title_sort |
hiv-2 infection: where are we today? |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Global Infectious Diseases |
issn |
0974-777X |
publishDate |
2013-01-01 |
description |
Context: The choice of antiretroviral therapy for HIV-2 differs from that for HIV-1, underscoring the importance of differentiating between the two. Aims: The current study was planned to find out the prevalence of HIV-2 infection at our center and to find out the utility of the current diagnostic algorithm in identifying the type of HIV infection. Setting and Design: Retrospective analysis in a tertiary care teaching institute over a period of three years. Materials and Methods: All patients diagnosed as HIV infected using NACO/WHO HIV testing strategy III were included in the study. They were classified as HIV-1 infected, HIV-2 infected and HIV-1 and HIV-2 co-infected based on their test results. For discordant samples, immunoblotting result from National Reference Laboratory was considered as final. Statistical Analysis Used: Comparison between HIV-1, HIV-2 and HIV-1+2 positive groups for age, gender, route of transmission was made using chi squared test. P value < 0.05 was considered as significant. Results: Of the total of 66,708 patients tested, 5,238 (7.9%) were positive for HIV antibodies. 7.62%, 0.14%, 0.08% and 0.004% were HIV-1, HIV-2, HIV-1 and HIV-2 co-infected and HIV type indeterminate (HIV-1 Indeterminate, 2+) respectively. The current algorithm could not differentiate between the types of HIV infection (as HIV-1 or HIV-2) in 63 (1.2%) cases. Conclusion: In areas like the Indian subcontinent, where epidemic of both HIV-1 and HIV-2 infections are ongoing, it is important to modify the current diagnostic algorithms to diagnose and confirm HIV-2 infections. |
topic |
HIV HIV epidemic HIV-2 Testing algorithm |
url |
http://www.jgid.org/article.asp?issn=0974-777X;year=2013;volume=5;issue=3;spage=110;epage=113;aulast=Ingole |
work_keys_str_mv |
AT nayanaaingole hiv2infectionwherearewetoday AT purvapsarkate hiv2infectionwherearewetoday AT supriyamparanjpe hiv2infectionwherearewetoday AT sameerdshinde hiv2infectionwherearewetoday AT sujataslall hiv2infectionwherearewetoday AT preetirmehta hiv2infectionwherearewetoday |
_version_ |
1725703678438932480 |