Altered cholesterol biosynthesis causes precocious neurogenesis in the developing mouse forebrain
We previously reported a mutation in the cholesterol biosynthesis gene, hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7rudolph), that results in striking embryonic forebrain dysgenesis. Here we describe abnormal patterns of neuroprogenitor proliferation in the mutant forebrain, namely, a decrease...
Main Authors: | Ashley M. Driver, Lisa E. Kratz, Richard I. Kelley, Rolf W. Stottmann |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-07-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996116300390 |
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