Propyl Gallate
The title compound, propyl gallate (<b>III</b>), is an important substance popularly used in the food, cosmetic and pharmaceutical industries. Current chemical syntheses of this compound are based on the acylation supported by thionyl chloride, DIC/DMAP or Fischer esterification using a...
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MDPI AG
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Online Access: | https://www.mdpi.com/1422-8599/2021/2/M1201 |
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doaj-3ce6050af5c84eb09a6d960869b5023c2021-04-12T23:04:43ZengMDPI AGMolbank1422-85992021-04-012021M1201M120110.3390/M1201Propyl GallateVan Hai Nguyen0Minh Ngoc Le1Hoa Binh Nguyen2Kieu Oanh Ha3Thai Ha Van Pham4Thi Hong Nguyen5Nguyet Suong Huyen Dao6Van Giang Nguyen7Dinh Luyen Nguyen8Nguyen Trieu Trinh9Department of Pharmaceutical Industry, Hanoi University of Pharmacy, Hanoi 110403, VietnamDepartment of Pharmaceutical Industry, Hanoi University of Pharmacy, Hanoi 110403, VietnamDepartment of Pharmaceutical Industry, Hanoi University of Pharmacy, Hanoi 110403, VietnamDepartment of Pharmaceutical Industry, Hanoi University of Pharmacy, Hanoi 110403, VietnamDepartment of Traditional Pharmacy, Hanoi University of Pharmacy, Hanoi 110403, VietnamLaboratory for Establishment of Reference Standards, National Institute of Drug Quality Control, Hanoi 11022, VietnamDepartment of Pharmaceutical Industry, Hanoi University of Pharmacy, Hanoi 110403, VietnamDepartment of Pharmaceutical Industry, Hanoi University of Pharmacy, Hanoi 110403, VietnamDepartment of Pharmaceutical Industry, Hanoi University of Pharmacy, Hanoi 110403, VietnamSchool of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, NSW 2308, AustraliaThe title compound, propyl gallate (<b>III</b>), is an important substance popularly used in the food, cosmetic and pharmaceutical industries. Current chemical syntheses of this compound are based on the acylation supported by thionyl chloride, DIC/DMAP or Fischer esterification using a range of homogenous and heterogenous catalysts. In this paper, an efficient, green, straightforward, and economical method for synthesizing propyl gallate using potassium hydrogen sulfate, KHSO<sub>4</sub>, as the heterogenous acidic catalyst has been developed for the first time. In addition, this paper provides a comprehensive spectral dataset for the title compound, especially the new data on DEPT and 2D NMR (HSQC and HMBC) spectra which are not currently available in the literature.https://www.mdpi.com/1422-8599/2021/2/M1201antioxidantesterificationpotassium hydrogen sulfatepropyl gallate |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Van Hai Nguyen Minh Ngoc Le Hoa Binh Nguyen Kieu Oanh Ha Thai Ha Van Pham Thi Hong Nguyen Nguyet Suong Huyen Dao Van Giang Nguyen Dinh Luyen Nguyen Nguyen Trieu Trinh |
spellingShingle |
Van Hai Nguyen Minh Ngoc Le Hoa Binh Nguyen Kieu Oanh Ha Thai Ha Van Pham Thi Hong Nguyen Nguyet Suong Huyen Dao Van Giang Nguyen Dinh Luyen Nguyen Nguyen Trieu Trinh Propyl Gallate Molbank antioxidant esterification potassium hydrogen sulfate propyl gallate |
author_facet |
Van Hai Nguyen Minh Ngoc Le Hoa Binh Nguyen Kieu Oanh Ha Thai Ha Van Pham Thi Hong Nguyen Nguyet Suong Huyen Dao Van Giang Nguyen Dinh Luyen Nguyen Nguyen Trieu Trinh |
author_sort |
Van Hai Nguyen |
title |
Propyl Gallate |
title_short |
Propyl Gallate |
title_full |
Propyl Gallate |
title_fullStr |
Propyl Gallate |
title_full_unstemmed |
Propyl Gallate |
title_sort |
propyl gallate |
publisher |
MDPI AG |
series |
Molbank |
issn |
1422-8599 |
publishDate |
2021-04-01 |
description |
The title compound, propyl gallate (<b>III</b>), is an important substance popularly used in the food, cosmetic and pharmaceutical industries. Current chemical syntheses of this compound are based on the acylation supported by thionyl chloride, DIC/DMAP or Fischer esterification using a range of homogenous and heterogenous catalysts. In this paper, an efficient, green, straightforward, and economical method for synthesizing propyl gallate using potassium hydrogen sulfate, KHSO<sub>4</sub>, as the heterogenous acidic catalyst has been developed for the first time. In addition, this paper provides a comprehensive spectral dataset for the title compound, especially the new data on DEPT and 2D NMR (HSQC and HMBC) spectra which are not currently available in the literature. |
topic |
antioxidant esterification potassium hydrogen sulfate propyl gallate |
url |
https://www.mdpi.com/1422-8599/2021/2/M1201 |
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1721529353912713216 |