An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase
The WD40 domain of the SCFCdc4ubiquitin ligase targets substrates via multiple phosphorylated degron motifs. The authors define a second degron-binding WD40 pocket that imparts a negative allosteric effect on binding to the primary pocket, and thereby enables the dynamic exchange of bound degrons.
Bibliographic Details
| Main Authors: |
Veronika Csizmok,
Stephen Orlicky,
Jing Cheng,
Jianhui Song,
Alaji Bah,
Neda Delgoshaie,
Hong Lin,
Tanja Mittag,
Frank Sicheri,
Hue Sun Chan,
Mike Tyers,
Julie D. Forman-Kay |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms13943
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