Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases
Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressive...
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doaj-3cfab927f930430097c73820302bcb502020-11-25T03:29:28ZengMDPI AGJournal of Clinical Medicine2077-03832020-03-019374610.3390/jcm9030746jcm9030746Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular DiseasesBahare Salehi0María L. Del Prado-Audelo1Hernán Cortés2Gerardo Leyva-Gómez3Zorica Stojanović-Radić4Yengkhom Disco Singh5Jayanta Kumar Patra6Gitishree Das7Natália Martins8Miquel Martorell9Marzieh Sharifi-Rad10William C. Cho11Javad Sharifi-Rad12Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, IranDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior S/N, Del. Coyoacán, Mexico City 04510, MexicoLaboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, MexicoDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior S/N, Del. Coyoacán, Mexico City 04510, MexicoDepartment of Biology and Ecology, Faculty of Science and Mathematics, University of Niš, 18000 Niš, SerbiaDepartment of Post-Harvest Technology, College of Horticulture and Forestry, Central Agricultural University, Pasighat 791102, Arunachal Pradesh, IndiaResearch Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi 10326, KoreaResearch Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi 10326, KoreaFaculty of Medicine, University of Porto, 4200-319 Porto, PortugalDepartment of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion 4070386, ChileResearch Department of Agronomy and Plant Breeding, Agricultural Research Institute, University of Zabol, Zabol 3585698613, IranDepartment of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, ChinaPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, IranCardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.https://www.mdpi.com/2077-0383/9/3/746curcumincardiovascular diseasenanomedicinenanocurcuminliposomenanoformulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bahare Salehi María L. Del Prado-Audelo Hernán Cortés Gerardo Leyva-Gómez Zorica Stojanović-Radić Yengkhom Disco Singh Jayanta Kumar Patra Gitishree Das Natália Martins Miquel Martorell Marzieh Sharifi-Rad William C. Cho Javad Sharifi-Rad |
spellingShingle |
Bahare Salehi María L. Del Prado-Audelo Hernán Cortés Gerardo Leyva-Gómez Zorica Stojanović-Radić Yengkhom Disco Singh Jayanta Kumar Patra Gitishree Das Natália Martins Miquel Martorell Marzieh Sharifi-Rad William C. Cho Javad Sharifi-Rad Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases Journal of Clinical Medicine curcumin cardiovascular disease nanomedicine nanocurcumin liposome nanoformulation |
author_facet |
Bahare Salehi María L. Del Prado-Audelo Hernán Cortés Gerardo Leyva-Gómez Zorica Stojanović-Radić Yengkhom Disco Singh Jayanta Kumar Patra Gitishree Das Natália Martins Miquel Martorell Marzieh Sharifi-Rad William C. Cho Javad Sharifi-Rad |
author_sort |
Bahare Salehi |
title |
Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases |
title_short |
Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases |
title_full |
Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases |
title_fullStr |
Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases |
title_full_unstemmed |
Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases |
title_sort |
therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-03-01 |
description |
Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems. |
topic |
curcumin cardiovascular disease nanomedicine nanocurcumin liposome nanoformulation |
url |
https://www.mdpi.com/2077-0383/9/3/746 |
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