Prevalence of neoplasms in patients with acromegaly – the need for a national registry
Introduction Acromegaly is an endocrine disorder caused predominantly by pituitary adenoma leading to autonomic oversecretion of growth hormone and secondary elevation of insulin-like growth factor 1 (IGF-1). Consequently, there are both theoretical and experimental grounds for establishing a correl...
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Institute of Rural Health
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doaj-3d101d4b92d64b11a462a85b0b0a72c12020-11-24T23:59:52ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632018-09-0125355956110.26444/aaem/8565285652Prevalence of neoplasms in patients with acromegaly – the need for a national registryBeata Matyjaszek-Matuszek0Ewa Obel1Marcin Lewicki2Jolanta Kowalczyk-Bołtuć3Agata Smoleń4Department of Endocrinology, Medical University, Lublin, PolandDepartment of Endocrinology, Medical University, Lublin, PolandDepartment of Endocrinology, Medical University, Lublin, PolandInstitute of Rural Health, Lublin, PolandDepartment of Epidemiology and Clinical Research Methodology, Medical University, Lublin, PolandIntroduction Acromegaly is an endocrine disorder caused predominantly by pituitary adenoma leading to autonomic oversecretion of growth hormone and secondary elevation of insulin-like growth factor 1 (IGF-1). Consequently, there are both theoretical and experimental grounds for establishing a correlation between this disorder and the higher incidence of neoplasms. Objective The aim of the study is to evaluate the incidence and types of neoplasms among patients with acromegaly. Material and methods The study included 67 patients with acromegaly, aged between 24 and 75±18.8 years, 46 women (68.7%) and 21 men (31.3%), BMI: 30.7±5.7 kg/m2, age at diagnosis 49.1±12.5 years, with the medians of GH and IGF-1 levels at diagnosis of 11.3 ng/ml and 663.8 ng/ml, respectively. A retrospective analysis of medical records with particular regard to physical examination, medical history, laboratory and imaging tests was performed. Results Fifty-one patients (76.1%) suffered from at least one neoplasm, among whom 48 patients (71.6%) had benign proliferations, whereas malignant neoplasms (larynx, endometrial and colon cancers) were found in only three patients (4.5%). Conclusions Benign neoplasms were found in majority of patients with acromegaly (71.6%) most notably: nodular goiter and colon polyps; malignant lesions were rare (4.5%). Only every fifth patient suffered from no neoplastic proliferations. No correlations between the studied parameters and the incidence of neoplasms were found, most likely due to the small number of patients. This is the reason for proposing the creating of the first national register of incidences of neoplasms among acromegalic patients.http://www.journalssystem.com/aaem/Prevalence-of-neoplasms-in-patients-with-acromegaly-a-need-for-national-registry,85652,0,2.htmlcanceracromegalyregistryIGF-1GHneoplasms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Beata Matyjaszek-Matuszek Ewa Obel Marcin Lewicki Jolanta Kowalczyk-Bołtuć Agata Smoleń |
spellingShingle |
Beata Matyjaszek-Matuszek Ewa Obel Marcin Lewicki Jolanta Kowalczyk-Bołtuć Agata Smoleń Prevalence of neoplasms in patients with acromegaly – the need for a national registry Annals of Agricultural and Environmental Medicine cancer acromegaly registry IGF-1 GH neoplasms |
author_facet |
Beata Matyjaszek-Matuszek Ewa Obel Marcin Lewicki Jolanta Kowalczyk-Bołtuć Agata Smoleń |
author_sort |
Beata Matyjaszek-Matuszek |
title |
Prevalence of neoplasms in patients with acromegaly – the need for a national registry |
title_short |
Prevalence of neoplasms in patients with acromegaly – the need for a national registry |
title_full |
Prevalence of neoplasms in patients with acromegaly – the need for a national registry |
title_fullStr |
Prevalence of neoplasms in patients with acromegaly – the need for a national registry |
title_full_unstemmed |
Prevalence of neoplasms in patients with acromegaly – the need for a national registry |
title_sort |
prevalence of neoplasms in patients with acromegaly – the need for a national registry |
publisher |
Institute of Rural Health |
series |
Annals of Agricultural and Environmental Medicine |
issn |
1232-1966 1898-2263 |
publishDate |
2018-09-01 |
description |
Introduction
Acromegaly is an endocrine disorder caused predominantly by pituitary adenoma leading to autonomic oversecretion of growth hormone and secondary elevation of insulin-like growth factor 1 (IGF-1). Consequently, there are both theoretical and experimental grounds for establishing a correlation between this disorder and the higher incidence of neoplasms.
Objective
The aim of the study is to evaluate the incidence and types of neoplasms among patients with acromegaly.
Material and methods
The study included 67 patients with acromegaly, aged between 24 and 75±18.8 years, 46 women (68.7%) and 21 men (31.3%), BMI: 30.7±5.7 kg/m2, age at diagnosis 49.1±12.5 years, with the medians of GH and IGF-1 levels at diagnosis of 11.3 ng/ml and 663.8 ng/ml, respectively. A retrospective analysis of medical records with particular regard to physical examination, medical history, laboratory and imaging tests was performed.
Results
Fifty-one patients (76.1%) suffered from at least one neoplasm, among whom 48 patients (71.6%) had benign proliferations, whereas malignant neoplasms (larynx, endometrial and colon cancers) were found in only three patients (4.5%).
Conclusions
Benign neoplasms were found in majority of patients with acromegaly (71.6%) most notably: nodular goiter and colon polyps; malignant lesions were rare (4.5%). Only every fifth patient suffered from no neoplastic proliferations. No correlations between the studied parameters and the incidence of neoplasms were found, most likely due to the small number of patients. This is the reason for proposing the creating of the first national register of incidences of neoplasms among acromegalic patients. |
topic |
cancer acromegaly registry IGF-1 GH neoplasms |
url |
http://www.journalssystem.com/aaem/Prevalence-of-neoplasms-in-patients-with-acromegaly-a-need-for-national-registry,85652,0,2.html |
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