Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization

Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization

The objective of this study was to develop and explore a novel CD133-targeting immunotoxin (IT) for use in combination with the endosomal escape method photochemical internalization (PCI). scFvCD133/rGelonin was recombinantly constructed by fusing a gene (scFvCD133) encoding the scFv that targets bo...

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Bibliographic Details
Main Authors: Cathrine Elisabeth Olsen, Lawrence H. Cheung, Anette Weyergang, Kristian Berg, Daniel A. Vallera, Michael G. Rosenblum, Pål Kristian Selbo
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Journal of Clinical Medicine
Subjects:
cancer stem cells
cd133
prominin-1
photochemical internalization
photodynamic therapy
immunotoxins
ribosome-inactivating proteins
drug delivery
Online Access:https://www.mdpi.com/2077-0383/9/1/68

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https://www.mdpi.com/2077-0383/9/1/68

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