GM1 and GM2 gangliosides: recent developments
GM1 and GM2 gangliosides are important components of the cell membrane and play an integral role in cell signaling and metabolism. In this conceptual overview, we discuss recent developments in our understanding of the basic biological functions of GM1 and GM2 and their involvement in several diseas...
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| Format: | Article |
| Language: | English |
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De Gruyter
2014-03-01
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| Series: | Biomolecular Concepts |
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| Online Access: | https://doi.org/10.1515/bmc-2013-0039 |
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doaj-3d234daeece54cecae3cea4a725ff0732021-09-05T20:42:34ZengDe GruyterBiomolecular Concepts1868-50211868-503X2014-03-0151879310.1515/bmc-2013-0039GM1 and GM2 gangliosides: recent developmentsBisel Blaine0Pavone Francesco S.1Calamai MartinoEuropean Laboratory for Non-linear Spectroscopy (LENS), University of Florence, 50019 Florence, ItalyEuropean Laboratory for Non-linear Spectroscopy (LENS), University of Florence, 50019 Florence, ItalyGM1 and GM2 gangliosides are important components of the cell membrane and play an integral role in cell signaling and metabolism. In this conceptual overview, we discuss recent developments in our understanding of the basic biological functions of GM1 and GM2 and their involvement in several diseases. In addition to a well-established spectrum of disorders known as gangliosidoses, such as Tay-Sachs disease, more and more evidence points at an involvement of GM1 in Alzheimer’s and Parkinson’s diseases. New emerging methodologies spanning from single-molecule imaging in vivo to simulations in silico have complemented standard studies based on ganglioside extraction.https://doi.org/10.1515/bmc-2013-0039gm1gm2membrane raftneurodegenerative diseasespolarization |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Bisel Blaine Pavone Francesco S. Calamai Martino |
| spellingShingle |
Bisel Blaine Pavone Francesco S. Calamai Martino GM1 and GM2 gangliosides: recent developments Biomolecular Concepts gm1 gm2 membrane raft neurodegenerative diseases polarization |
| author_facet |
Bisel Blaine Pavone Francesco S. Calamai Martino |
| author_sort |
Bisel Blaine |
| title |
GM1 and GM2 gangliosides: recent developments |
| title_short |
GM1 and GM2 gangliosides: recent developments |
| title_full |
GM1 and GM2 gangliosides: recent developments |
| title_fullStr |
GM1 and GM2 gangliosides: recent developments |
| title_full_unstemmed |
GM1 and GM2 gangliosides: recent developments |
| title_sort |
gm1 and gm2 gangliosides: recent developments |
| publisher |
De Gruyter |
| series |
Biomolecular Concepts |
| issn |
1868-5021 1868-503X |
| publishDate |
2014-03-01 |
| description |
GM1 and GM2 gangliosides are important components of the cell membrane and play an integral role in cell signaling and metabolism. In this conceptual overview, we discuss recent developments in our understanding of the basic biological functions of GM1 and GM2 and their involvement in several diseases. In addition to a well-established spectrum of disorders known as gangliosidoses, such as Tay-Sachs disease, more and more evidence points at an involvement of GM1 in Alzheimer’s and Parkinson’s diseases. New emerging methodologies spanning from single-molecule imaging in vivo to simulations in silico have complemented standard studies based on ganglioside extraction. |
| topic |
gm1 gm2 membrane raft neurodegenerative diseases polarization |
| url |
https://doi.org/10.1515/bmc-2013-0039 |
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AT biselblaine gm1andgm2gangliosidesrecentdevelopments AT pavonefrancescos gm1andgm2gangliosidesrecentdevelopments AT calamaimartino gm1andgm2gangliosidesrecentdevelopments |
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