Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases
There has been an increasing prevalence of neurodegenerative diseases with the rapid increase in aging societies worldwide. Biomarkers that can be used to detect pathological changes before the development of severe neuronal loss and consequently facilitate early intervention with disease-modifying...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/10/5216 |
id |
doaj-3d249562477145f38d139860b3d8c1b0 |
---|---|
record_format |
Article |
spelling |
doaj-3d249562477145f38d139860b3d8c1b02021-06-01T00:04:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01225216521610.3390/ijms22105216Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative DiseasesKoji Kamagata0Christina Andica1Ayumi Kato2Yuya Saito3Wataru Uchida4Taku Hatano5Matthew Lukies6Takashi Ogawa7Haruka Takeshige-Amano8Toshiaki Akashi9Akifumi Hagiwara10Shohei Fujita11Shigeki Aoki12Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, JapanDepartment of Diagnostic and Interventional Radiology, Alfred Health, Melbourne, VIC 3004, AustraliaDepartment of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, JapanDepartment of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, JapanDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, JapanThere has been an increasing prevalence of neurodegenerative diseases with the rapid increase in aging societies worldwide. Biomarkers that can be used to detect pathological changes before the development of severe neuronal loss and consequently facilitate early intervention with disease-modifying therapeutic modalities are therefore urgently needed. Diffusion magnetic resonance imaging (MRI) is a promising tool that can be used to infer microstructural characteristics of the brain, such as microstructural integrity and complexity, as well as axonal density, order, and myelination, through the utilization of water molecules that are diffused within the tissue, with displacement at the micron scale. Diffusion tensor imaging is the most commonly used diffusion MRI technique to assess the pathophysiology of neurodegenerative diseases. However, diffusion tensor imaging has several limitations, and new technologies, including neurite orientation dispersion and density imaging, diffusion kurtosis imaging, and free-water imaging, have been recently developed as approaches to overcome these constraints. This review provides an overview of these technologies and their potential as biomarkers for the early diagnosis and disease progression of major neurodegenerative diseases.https://www.mdpi.com/1422-0067/22/10/5216Alzheimer’s diseaseamyotrophic lateral sclerosisbiomarkerdiffusion kurtosis imagingdiffusion tensor imagingfree-water imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Koji Kamagata Christina Andica Ayumi Kato Yuya Saito Wataru Uchida Taku Hatano Matthew Lukies Takashi Ogawa Haruka Takeshige-Amano Toshiaki Akashi Akifumi Hagiwara Shohei Fujita Shigeki Aoki |
spellingShingle |
Koji Kamagata Christina Andica Ayumi Kato Yuya Saito Wataru Uchida Taku Hatano Matthew Lukies Takashi Ogawa Haruka Takeshige-Amano Toshiaki Akashi Akifumi Hagiwara Shohei Fujita Shigeki Aoki Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases International Journal of Molecular Sciences Alzheimer’s disease amyotrophic lateral sclerosis biomarker diffusion kurtosis imaging diffusion tensor imaging free-water imaging |
author_facet |
Koji Kamagata Christina Andica Ayumi Kato Yuya Saito Wataru Uchida Taku Hatano Matthew Lukies Takashi Ogawa Haruka Takeshige-Amano Toshiaki Akashi Akifumi Hagiwara Shohei Fujita Shigeki Aoki |
author_sort |
Koji Kamagata |
title |
Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title_short |
Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title_full |
Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title_fullStr |
Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title_full_unstemmed |
Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title_sort |
diffusion magnetic resonance imaging-based biomarkers for neurodegenerative diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-05-01 |
description |
There has been an increasing prevalence of neurodegenerative diseases with the rapid increase in aging societies worldwide. Biomarkers that can be used to detect pathological changes before the development of severe neuronal loss and consequently facilitate early intervention with disease-modifying therapeutic modalities are therefore urgently needed. Diffusion magnetic resonance imaging (MRI) is a promising tool that can be used to infer microstructural characteristics of the brain, such as microstructural integrity and complexity, as well as axonal density, order, and myelination, through the utilization of water molecules that are diffused within the tissue, with displacement at the micron scale. Diffusion tensor imaging is the most commonly used diffusion MRI technique to assess the pathophysiology of neurodegenerative diseases. However, diffusion tensor imaging has several limitations, and new technologies, including neurite orientation dispersion and density imaging, diffusion kurtosis imaging, and free-water imaging, have been recently developed as approaches to overcome these constraints. This review provides an overview of these technologies and their potential as biomarkers for the early diagnosis and disease progression of major neurodegenerative diseases. |
topic |
Alzheimer’s disease amyotrophic lateral sclerosis biomarker diffusion kurtosis imaging diffusion tensor imaging free-water imaging |
url |
https://www.mdpi.com/1422-0067/22/10/5216 |
work_keys_str_mv |
AT kojikamagata diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT christinaandica diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT ayumikato diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT yuyasaito diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT wataruuchida diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT takuhatano diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT matthewlukies diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT takashiogawa diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT harukatakeshigeamano diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT toshiakiakashi diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT akifumihagiwara diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT shoheifujita diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases AT shigekiaoki diffusionmagneticresonanceimagingbasedbiomarkersforneurodegenerativediseases |
_version_ |
1721415762395004928 |