A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells

Futrega et al. challenge the long established chondrogenic differentiation protocol used to induce bone marrow-derived stromal cell (BMSC) differentiation which presumes the need for more than 2 weeks of continuous TGF-β1 exposure. Using a micro-pellet model, they show that BMSC differentiation is t...

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Main Authors:	Kathryn Futrega, Pamela G. Robey, Travis J. Klein, Ross W. Crawford, Michael R. Doran
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-020-01520-0

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spelling	doaj-3d2fae483ee04c689e0ddf9c60a6d72c2021-01-10T12:41:47ZengNature Publishing GroupCommunications Biology2399-36422021-01-014111210.1038/s42003-020-01520-0A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cellsKathryn Futrega0Pamela G. Robey1Travis J. Klein2Ross W. Crawford3Michael R. Doran4National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Department of Health and Human ServicesNational Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Department of Health and Human ServicesCentre for Biomedical Technologies (CBT), Queensland University of Technology (QUT)Centre for Biomedical Technologies (CBT), Queensland University of Technology (QUT)National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Department of Health and Human ServicesFutrega et al. challenge the long established chondrogenic differentiation protocol used to induce bone marrow-derived stromal cell (BMSC) differentiation which presumes the need for more than 2 weeks of continuous TGF-β1 exposure. Using a micro-pellet model, they show that BMSC differentiation is triggered by a single day of TGF-β1 exposure.https://doi.org/10.1038/s42003-020-01520-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kathryn Futrega Pamela G. Robey Travis J. Klein Ross W. Crawford Michael R. Doran
spellingShingle	Kathryn Futrega Pamela G. Robey Travis J. Klein Ross W. Crawford Michael R. Doran A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells Communications Biology
author_facet	Kathryn Futrega Pamela G. Robey Travis J. Klein Ross W. Crawford Michael R. Doran
author_sort	Kathryn Futrega
title	A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
title_short	A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
title_full	A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
title_fullStr	A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
title_full_unstemmed	A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
title_sort	single day of tgf-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-01-01
description	Futrega et al. challenge the long established chondrogenic differentiation protocol used to induce bone marrow-derived stromal cell (BMSC) differentiation which presumes the need for more than 2 weeks of continuous TGF-β1 exposure. Using a micro-pellet model, they show that BMSC differentiation is triggered by a single day of TGF-β1 exposure.
url	https://doi.org/10.1038/s42003-020-01520-0
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A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells

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