Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga toxins and Host Damage-Associated Molecular Patterns

Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga toxins and Host Damage-Associated Molecular Patterns

Hemolytic uremic syndrome (HUS) from enterohemorrhagic E.coli infection (EHEC) is a leading cause of kidney failure in otherwise healthy U.S. children. The bacterial Shiga toxins (Stx) induce the characteristic coagulopathy of HUS, but the cell and organ damage during infection likely also releases...

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Bibliographic Details
Main Authors: Chad L Mayer, Caitlin S.L. Parello, Benjamin C Lee, Kiyoshi eItagaki, Shinichiro eKurosawa, DJ eStearns-Kurosawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Immunology
Subjects:
Protein C
Shiga Toxin 1
Shiga Toxin 2
hemolytic uremic syndrome (HUS)
damage-associated molecular patterns (DAMPs)
endothelial cells)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00155/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00155/full

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