Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga toxins and Host Damage-Associated Molecular Patterns
Hemolytic uremic syndrome (HUS) from enterohemorrhagic E.coli infection (EHEC) is a leading cause of kidney failure in otherwise healthy U.S. children. The bacterial Shiga toxins (Stx) induce the characteristic coagulopathy of HUS, but the cell and organ damage during infection likely also releases...
Main Authors: | Chad L Mayer, Caitlin S.L. Parello, Benjamin C Lee, Kiyoshi eItagaki, Shinichiro eKurosawa, DJ eStearns-Kurosawa |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-04-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00155/full |
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