Factors that modulate olfactory dysfunction
The olfactory system is one of a few areas in the nervous system which is capable of regeneration throughout the life. Olfactory sensory neurons reside in the nasal cavity are continuously replenished with new neurons arising from stem cells. Some factors such as aging, neurodegenerative diseases, h...
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Wolters Kluwer Medknow Publications
2018-01-01
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doaj-3d46600a7cd949c684ed058bfddb81282020-11-25T03:18:46ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742018-01-011371151115510.4103/1673-5374.235018Factors that modulate olfactory dysfunctionKate BeecherJames A St JohnFatemeh ChehrehasaThe olfactory system is one of a few areas in the nervous system which is capable of regeneration throughout the life. Olfactory sensory neurons reside in the nasal cavity are continuously replenished with new neurons arising from stem cells. Some factors such as aging, neurodegenerative diseases, head trauma, brain tumor extraction and infection cause olfactory dysfunction which significantly influences physical wellbeing, quality of life, mental health, nutritional status, memory processes, identifying danger and is associated with increased mortality. Therefore, finding a treatment to improve olfactory dysfunction is needed. Recent research efforts in the field have shown some very promising new approaches to treat olfactory dysfunction. This review explores the current studies that have addressed therapeutic approaches to improve olfactory neuron regeneration based on cell transplantation therapy, modulation of physiological olfactory dysfunction and drug treatments.http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=7;spage=1151;epage=1155;aulast=Beecherolfactory; neuron; regeneration; anosmia; loss of smell; degeneration; bulbectomy; ensheathing cells; growth factor; epithelium; receptor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kate Beecher James A St John Fatemeh Chehrehasa |
spellingShingle |
Kate Beecher James A St John Fatemeh Chehrehasa Factors that modulate olfactory dysfunction Neural Regeneration Research olfactory; neuron; regeneration; anosmia; loss of smell; degeneration; bulbectomy; ensheathing cells; growth factor; epithelium; receptor |
author_facet |
Kate Beecher James A St John Fatemeh Chehrehasa |
author_sort |
Kate Beecher |
title |
Factors that modulate olfactory dysfunction |
title_short |
Factors that modulate olfactory dysfunction |
title_full |
Factors that modulate olfactory dysfunction |
title_fullStr |
Factors that modulate olfactory dysfunction |
title_full_unstemmed |
Factors that modulate olfactory dysfunction |
title_sort |
factors that modulate olfactory dysfunction |
publisher |
Wolters Kluwer Medknow Publications |
series |
Neural Regeneration Research |
issn |
1673-5374 |
publishDate |
2018-01-01 |
description |
The olfactory system is one of a few areas in the nervous system which is capable of regeneration throughout the life. Olfactory sensory neurons reside in the nasal cavity are continuously replenished with new neurons arising from stem cells. Some factors such as aging, neurodegenerative diseases, head trauma, brain tumor extraction and infection cause olfactory dysfunction which significantly influences physical wellbeing, quality of life, mental health, nutritional status, memory processes, identifying danger and is associated with increased mortality. Therefore, finding a treatment to improve olfactory dysfunction is needed. Recent research efforts in the field have shown some very promising new approaches to treat olfactory dysfunction. This review explores the current studies that have addressed therapeutic approaches to improve olfactory neuron regeneration based on cell transplantation therapy, modulation of physiological olfactory dysfunction and drug treatments. |
topic |
olfactory; neuron; regeneration; anosmia; loss of smell; degeneration; bulbectomy; ensheathing cells; growth factor; epithelium; receptor |
url |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=7;spage=1151;epage=1155;aulast=Beecher |
work_keys_str_mv |
AT katebeecher factorsthatmodulateolfactorydysfunction AT jamesastjohn factorsthatmodulateolfactorydysfunction AT fatemehchehrehasa factorsthatmodulateolfactorydysfunction |
_version_ |
1724625901957677056 |