Impact of KLF4 on Cell Proliferation and Epithelial Differentiation in the Context of Cystic Fibrosis

Impact of KLF4 on Cell Proliferation and Epithelial Differentiation in the Context of Cystic Fibrosis

Cystic fibrosis (CF) cells display a more cancer-like phenotype vs. non-CF cells. KLF4 overexpression has been described in CF and this transcriptional factor acts as a negative regulator of wt-CFTR. KLF4 is described as exerting its effects in a cell-context-dependent fashion, but it is generally c...

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Bibliographic Details
Main Authors: Luís Sousa, Ines Pankonien, Filipa B. Simões, Marc Chanson, Margarida D. Amaral
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
KLF4
wound healing
epithelial differentiation
proliferation
cystic fibrosis
Online Access:https://www.mdpi.com/1422-0067/21/18/6717

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