Foot-and-Mouth Disease Virus Lacking the Leader Protein and Containing Two Negative DIVA Markers (FMDV LL3B3D A<sub>24</sub>) Is Highly Attenuated in Pigs

Foot-and-Mouth Disease Virus Lacking the Leader Protein and Containing Two Negative DIVA Markers (FMDV LL3B3D A<sub>24</sub>) Is Highly Attenuated in Pigs

Inactivated whole-virus vaccines are widely used for the control of foot-and-mouth disease (FMD). Their production requires the growth of large quantities of virulent FMD virus in biocontainment facilities, which is expensive and carries the risk of an inadvertent release of virus. Attenuated recomb...

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Bibliographic Details
Main Authors: Michael Eschbaumer, Veronika Dill, Jolene C. Carlson, Jonathan Arzt, Carolina Stenfeldt, Peter W. Krug, John M. Hardham, Jacob E. Stegner, Luis L. Rodriguez, Elizabeth Rieder
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pathogens
Subjects:
leaderless
marker virus
attenuated
foot-and-mouth disease virus
diva
Online Access:https://www.mdpi.com/2076-0817/9/2/129

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