Structure-Based Virtual Screening and Identification of Potential Inhibitors of SARS-CoV-2 S-RBD and ACE2 Interaction

Structure-Based Virtual Screening and Identification of Potential Inhibitors of SARS-CoV-2 S-RBD and ACE2 Interaction

The emergence and rapid spread of SARS-CoV-2 have caused a worldwide public health crisis. Designing small molecule inhibitors targeting SARS-CoV-2 S-RBD/ACE2 interaction is considered as a potential strategy for the prevention and treatment of SARS-CoV-2. But to date, only a few compounds have been...

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Bibliographic Details
Main Authors: Jiacheng Xiong, Yusen Xiang, Ziming Huang, Xiaohong Liu, Mengge Wang, Guangbo Ge, Hongzhuan Chen, Jianrong Xu, Mingyue Zheng, Lili Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Chemistry
Subjects:
SARS-CoV-2
angiotensin-converting enzyme 2 (ACE2)
spike protein receptor-binding domain (S-RBD)
structure-based virtual screening
protein-protein interaction (PPI) inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.740702/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.740702/full

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