A scalable approach for discovering conserved active subnetworks across species.

Overlaying differential changes in gene expression on protein interaction networks has proven to be a useful approach to interpreting the cell's dynamic response to a changing environment. Despite successes in finding active subnetworks in the context of a single species, the idea of overlaying...

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Bibliographic Details
Main Authors: Raamesh Deshpande, Shikha Sharma, Catherine M Verfaillie, Wei-Shou Hu, Chad L Myers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3000367?pdf=render