Choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia.
Validation of choroidal thickness and other biometrics measured by spectral domain optical coherence tomography (SD-OCT) in predicting lacquer cracks formation in highly myopic eyes.Patients with a refractive error worse than -8 diopters and moderate myopic maculopathy were recruited into two groups...
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doaj-3d6ca079d3724011a884d98504b95cdc2020-11-25T01:21:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5366010.1371/journal.pone.0053660Choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia.Nan-Kai WangChi-Chun LaiChai Lin ChouYen-Po ChenLan-Hsin ChuangAn-Ning ChaoHsiao-Jung TsengChee-Jen ChangWei-Chi WuKuan-Jen ChenStephen H TsangValidation of choroidal thickness and other biometrics measured by spectral domain optical coherence tomography (SD-OCT) in predicting lacquer cracks formation in highly myopic eyes.Patients with a refractive error worse than -8 diopters and moderate myopic maculopathy were recruited into two groups based on the presence or absence of lacquer cracks (36 eyes without and 33 eyes with lacquer cracks). Choroidal thickness, refractive error, and axial length were measured and subjected to receiver operating characteristic curve analysis to identify the optimal cutoff values at predicting lacquer crack formation. The width of the retinal pigment epithelium (RPE), RPE to the inner segment/outer segment line, RPE to the external limiting membrane were also measured and compared to the subfoveal choroidal thickness to assess their relationships as potential markers of lacquer crack formation.Lacquer crack is associated with decreased choroidal thickness, lower best-corrected visual acuity, longer axial length and higher refractive errors. Choroidal thickness has the strongest association with lacquer crack formation versus axial length and refractive error. In eyes with lacquer cracks, stellate lacquer cracks are associated with thinner choroidal thickness compared to eyes with linear lacquer cracks. Subfoveal choroidal thickness less than the width of the retinal pigment epithelium to the inner segment/outer segment line is also associated with lacquer crack formation (sensitivity 78.8%, specificity 88.3%, and accuracy 81.2%).This study suggests that choroidal thickness and other SD-OCT measurements could be employed clinically to predict the development and severity of lacquer cracks in patients with high myopia.http://europepmc.org/articles/PMC3551908?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nan-Kai Wang Chi-Chun Lai Chai Lin Chou Yen-Po Chen Lan-Hsin Chuang An-Ning Chao Hsiao-Jung Tseng Chee-Jen Chang Wei-Chi Wu Kuan-Jen Chen Stephen H Tsang |
spellingShingle |
Nan-Kai Wang Chi-Chun Lai Chai Lin Chou Yen-Po Chen Lan-Hsin Chuang An-Ning Chao Hsiao-Jung Tseng Chee-Jen Chang Wei-Chi Wu Kuan-Jen Chen Stephen H Tsang Choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia. PLoS ONE |
author_facet |
Nan-Kai Wang Chi-Chun Lai Chai Lin Chou Yen-Po Chen Lan-Hsin Chuang An-Ning Chao Hsiao-Jung Tseng Chee-Jen Chang Wei-Chi Wu Kuan-Jen Chen Stephen H Tsang |
author_sort |
Nan-Kai Wang |
title |
Choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia. |
title_short |
Choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia. |
title_full |
Choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia. |
title_fullStr |
Choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia. |
title_full_unstemmed |
Choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia. |
title_sort |
choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Validation of choroidal thickness and other biometrics measured by spectral domain optical coherence tomography (SD-OCT) in predicting lacquer cracks formation in highly myopic eyes.Patients with a refractive error worse than -8 diopters and moderate myopic maculopathy were recruited into two groups based on the presence or absence of lacquer cracks (36 eyes without and 33 eyes with lacquer cracks). Choroidal thickness, refractive error, and axial length were measured and subjected to receiver operating characteristic curve analysis to identify the optimal cutoff values at predicting lacquer crack formation. The width of the retinal pigment epithelium (RPE), RPE to the inner segment/outer segment line, RPE to the external limiting membrane were also measured and compared to the subfoveal choroidal thickness to assess their relationships as potential markers of lacquer crack formation.Lacquer crack is associated with decreased choroidal thickness, lower best-corrected visual acuity, longer axial length and higher refractive errors. Choroidal thickness has the strongest association with lacquer crack formation versus axial length and refractive error. In eyes with lacquer cracks, stellate lacquer cracks are associated with thinner choroidal thickness compared to eyes with linear lacquer cracks. Subfoveal choroidal thickness less than the width of the retinal pigment epithelium to the inner segment/outer segment line is also associated with lacquer crack formation (sensitivity 78.8%, specificity 88.3%, and accuracy 81.2%).This study suggests that choroidal thickness and other SD-OCT measurements could be employed clinically to predict the development and severity of lacquer cracks in patients with high myopia. |
url |
http://europepmc.org/articles/PMC3551908?pdf=render |
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