A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy
Abstract Aims Few investigations have been conducted to identify genetic determinants of common, polygenetic forms of heart failure (HF), and only a limited number of these genetic associations have been validated by multiple groups. Methods and results We performed a case–control study to further i...
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doaj-3d6e05a5bc794595a3acaeab71ce9ed82021-02-24T06:51:30ZengWileyESC Heart Failure2055-58222020-12-01764384438910.1002/ehf2.12934A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathySimon deDenus0Fannie Mottet1Sandra Korol2Yassamin Feroz Zada3Sylvie Provost4Ian Mongrain5Géraldine Asselin6Essaïd Oussaïd7David Busseuil8Guillaume Lettre9John Rioux10Normand Racine11Eileen O'Meara12Michel White13Jean Rouleau14Jean Claude Tardif15Marie‐Pierre Dubé16Montreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaFaculty of Pharmacy Université de Montréal Montreal QC CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaMontreal Heart Institute 5000 Bélanger Montreal QC H1T 1C8 CanadaAbstract Aims Few investigations have been conducted to identify genetic determinants of common, polygenetic forms of heart failure (HF), and only a limited number of these genetic associations have been validated by multiple groups. Methods and results We performed a case–control study to further investigate the potential impact of 14 previously reported candidate genes on the risk of HF and specific HF sub‐types. We also performed an exploratory genome‐wide study. We included 799 patients with HF and 1529 controls. After adjusting for age, sex, and genetic ancestry, we found that the C allele of rs2234962 in BAG3 was associated with a decreased risk of idiopathic dilated cardiomyopathy (odds ratio 0.42, 95% confidence interval 0.25–0.68, P = 0.0005), consistent with a previous report. No association for the other primary variants or exploratory genome‐wide study was found. Conclusions Our findings provide independent replication for the association between a common coding variant (rs2234962) in BAG3 and the risk of idiopathic dilated cardiomyopathy.https://doi.org/10.1002/ehf2.12934Heart failureGeneticsB‐cell lymphoma 2‐associated anthanogene protein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Simon deDenus Fannie Mottet Sandra Korol Yassamin Feroz Zada Sylvie Provost Ian Mongrain Géraldine Asselin Essaïd Oussaïd David Busseuil Guillaume Lettre John Rioux Normand Racine Eileen O'Meara Michel White Jean Rouleau Jean Claude Tardif Marie‐Pierre Dubé |
spellingShingle |
Simon deDenus Fannie Mottet Sandra Korol Yassamin Feroz Zada Sylvie Provost Ian Mongrain Géraldine Asselin Essaïd Oussaïd David Busseuil Guillaume Lettre John Rioux Normand Racine Eileen O'Meara Michel White Jean Rouleau Jean Claude Tardif Marie‐Pierre Dubé A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy ESC Heart Failure Heart failure Genetics B‐cell lymphoma 2‐associated anthanogene protein |
author_facet |
Simon deDenus Fannie Mottet Sandra Korol Yassamin Feroz Zada Sylvie Provost Ian Mongrain Géraldine Asselin Essaïd Oussaïd David Busseuil Guillaume Lettre John Rioux Normand Racine Eileen O'Meara Michel White Jean Rouleau Jean Claude Tardif Marie‐Pierre Dubé |
author_sort |
Simon deDenus |
title |
A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy |
title_short |
A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy |
title_full |
A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy |
title_fullStr |
A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy |
title_full_unstemmed |
A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy |
title_sort |
genetic association study of heart failure: more evidence for the role of bag3 in idiopathic dilated cardiomyopathy |
publisher |
Wiley |
series |
ESC Heart Failure |
issn |
2055-5822 |
publishDate |
2020-12-01 |
description |
Abstract Aims Few investigations have been conducted to identify genetic determinants of common, polygenetic forms of heart failure (HF), and only a limited number of these genetic associations have been validated by multiple groups. Methods and results We performed a case–control study to further investigate the potential impact of 14 previously reported candidate genes on the risk of HF and specific HF sub‐types. We also performed an exploratory genome‐wide study. We included 799 patients with HF and 1529 controls. After adjusting for age, sex, and genetic ancestry, we found that the C allele of rs2234962 in BAG3 was associated with a decreased risk of idiopathic dilated cardiomyopathy (odds ratio 0.42, 95% confidence interval 0.25–0.68, P = 0.0005), consistent with a previous report. No association for the other primary variants or exploratory genome‐wide study was found. Conclusions Our findings provide independent replication for the association between a common coding variant (rs2234962) in BAG3 and the risk of idiopathic dilated cardiomyopathy. |
topic |
Heart failure Genetics B‐cell lymphoma 2‐associated anthanogene protein |
url |
https://doi.org/10.1002/ehf2.12934 |
work_keys_str_mv |
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