MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm
Abstract Objective: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than co...
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Sociedade Brasileira de Cirurgia Cardiovascular
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doaj-3d70ce987345475d92136ae5e7c66f4f2020-11-24T21:19:02ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery1678-974132321522410.21470/1678-9741-2016-0050S0102-76382017000300215MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic AneurysmEdwaldo Edner JovilianoMauricio Serra RibeiroEmanuel Junior Ramos TenorioAbstract Objective: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a complex multifactorial process, involving destructive remodeling of the connective tissue around the affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs that control diverse cellular functions by promoting degradation or inhibition of translation of specific mRNAs. A profile aberrant expression of miRNAs has been linked to human diseases, including cardiovascular dysfunction.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382017000300215&lng=en&tlng=enAortic AneurysmAortic Aneurysm, AbdominalMicroRNAs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Edwaldo Edner Joviliano Mauricio Serra Ribeiro Emanuel Junior Ramos Tenorio |
spellingShingle |
Edwaldo Edner Joviliano Mauricio Serra Ribeiro Emanuel Junior Ramos Tenorio MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm Brazilian Journal of Cardiovascular Surgery Aortic Aneurysm Aortic Aneurysm, Abdominal MicroRNAs |
author_facet |
Edwaldo Edner Joviliano Mauricio Serra Ribeiro Emanuel Junior Ramos Tenorio |
author_sort |
Edwaldo Edner Joviliano |
title |
MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm |
title_short |
MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm |
title_full |
MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm |
title_fullStr |
MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm |
title_full_unstemmed |
MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm |
title_sort |
micrornas and current concepts on the pathogenesis of abdominal aortic aneurysm |
publisher |
Sociedade Brasileira de Cirurgia Cardiovascular |
series |
Brazilian Journal of Cardiovascular Surgery |
issn |
1678-9741 |
description |
Abstract Objective: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a complex multifactorial process, involving destructive remodeling of the connective tissue around the affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs that control diverse cellular functions by promoting degradation or inhibition of translation of specific mRNAs. A profile aberrant expression of miRNAs has been linked to human diseases, including cardiovascular dysfunction. |
topic |
Aortic Aneurysm Aortic Aneurysm, Abdominal MicroRNAs |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382017000300215&lng=en&tlng=en |
work_keys_str_mv |
AT edwaldoednerjoviliano micrornasandcurrentconceptsonthepathogenesisofabdominalaorticaneurysm AT mauricioserraribeiro micrornasandcurrentconceptsonthepathogenesisofabdominalaorticaneurysm AT emanueljuniorramostenorio micrornasandcurrentconceptsonthepathogenesisofabdominalaorticaneurysm |
_version_ |
1726007114499883008 |