Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8+ T Cell Proliferation

Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8+ T Cell Proliferation

Natural Killer (NK) cells play a key role in cancer immunosurveillance. However, NK cells from cancer patients display an altered phenotype and impaired effector functions. In addition, evidence of a regulatory role for NK cells is emerging in diverse models of viral infection, transplantation, and...

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Bibliographic Details
Main Authors: Jessica M. Sierra, Florencia Secchiari, Sol Y. Nuñez, Ximena L. Raffo Iraolagoitia, Andrea Ziblat, Adrián D. Friedrich, María V. Regge, M. Cecilia Santilli, Nicolás I. Torres, Mariana Gantov, Aldana Trotta, Carlos Ameri, Gonzalo Vitagliano, Hernando Ríos Pita, Luis Rico, Agustín Rovegno, Nicolás Richards, Carolina I. Domaica, Norberto W. Zwirner, Mercedes B. Fuertes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
NK cells
PD-L1
CD8+ T cells
regulation
renal cell carcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.745939/full

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