Thrombomodulin and Thrombopoietin, Two Biomarkers of Hemostasis, Are Positively Associated with Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a Population-Based Cross-Sectional Study
A pro-coagulative state is related to increased risk of cardiovascular diseases but also certain cancers. Since experimental and smaller human studies suggest that diet, physical activity, and body weight may all affect coagulation, we evaluated associations between these lifestyle factors and hemos...
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doaj-3d972246fa7b4f30972ea8c5de9a986c2020-11-25T01:46:07ZengMDPI AGNutrients2072-66432019-09-01119206710.3390/nu11092067nu11092067Thrombomodulin and Thrombopoietin, Two Biomarkers of Hemostasis, Are Positively Associated with Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a Population-Based Cross-Sectional StudyMirja Grafetstätter0Laura Pletsch-Borba1Disorn Sookthai2Nena Karavasiloglou3Theron Johnson4Verena A. Katzke5Michael Hoffmeister6Peter Bugert7Rudolf Kaaks8Tilman Kühn9Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, GermanyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, GermanyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, GermanyDivision of Chronic Disease Epidemiology, Institute for Epidemiology, Biostatistics and Prevention, University of Zürich, 8001 Zürich, SwitzerlandDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, GermanyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, GermanyDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, GermanyInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, and German Red Cross Blood Service, Friedrich-Ebert-Str. 107, 68167 Mannheim, GermanyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, GermanyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, GermanyA pro-coagulative state is related to increased risk of cardiovascular diseases but also certain cancers. Since experimental and smaller human studies suggest that diet, physical activity, and body weight may all affect coagulation, we evaluated associations between these lifestyle factors and hemostatic biomarkers in a population-based study. Cross-sectional baseline data from 2267 randomly selected participants of EPIC-Heidelberg (age range 35−65 years) was used. Fibrinogen, glycoprotein IIb/IIIa, P-selectin, thrombomodulin (TM), and thrombopoietin (TPO) were measured in baseline plasma samples. A score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations for cancer prevention was created. Associations between the WCRF/AICR score as well as its individual components and hemostatic biomarkers were analyzed by linear regression models. Multivariable-adjusted geometric means (95% confidence intervals) of TM and TPO were higher with greater adherence to the WCRF/AICR recommendations (TM, lowest vs. highest score category: 2.90 (2.7,3.1) vs. 3.10 (2.9,3.3) ng/mL, <i>p</i><sub>linear trend</sub> = 0.0001; TPO: 328 (302,356) vs. 348 (321,378) pg/mL, <i>p</i><sub>linear trend</sub> = 0.0007). These associations were driven by lower alcohol and meat consumption among persons with higher WCRF/AICR scores. Our results indicate that lifestyle factors favorably affect TM and TPO, two hemostatic factors implicated in chronic disease development.https://www.mdpi.com/2072-6643/11/9/2067lifestylecoagulationthrombomodulinthrombopoietinfibrinogencancer preventionWCRF/AICR recommendations |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mirja Grafetstätter Laura Pletsch-Borba Disorn Sookthai Nena Karavasiloglou Theron Johnson Verena A. Katzke Michael Hoffmeister Peter Bugert Rudolf Kaaks Tilman Kühn |
spellingShingle |
Mirja Grafetstätter Laura Pletsch-Borba Disorn Sookthai Nena Karavasiloglou Theron Johnson Verena A. Katzke Michael Hoffmeister Peter Bugert Rudolf Kaaks Tilman Kühn Thrombomodulin and Thrombopoietin, Two Biomarkers of Hemostasis, Are Positively Associated with Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a Population-Based Cross-Sectional Study Nutrients lifestyle coagulation thrombomodulin thrombopoietin fibrinogen cancer prevention WCRF/AICR recommendations |
author_facet |
Mirja Grafetstätter Laura Pletsch-Borba Disorn Sookthai Nena Karavasiloglou Theron Johnson Verena A. Katzke Michael Hoffmeister Peter Bugert Rudolf Kaaks Tilman Kühn |
author_sort |
Mirja Grafetstätter |
title |
Thrombomodulin and Thrombopoietin, Two Biomarkers of Hemostasis, Are Positively Associated with Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a Population-Based Cross-Sectional Study |
title_short |
Thrombomodulin and Thrombopoietin, Two Biomarkers of Hemostasis, Are Positively Associated with Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a Population-Based Cross-Sectional Study |
title_full |
Thrombomodulin and Thrombopoietin, Two Biomarkers of Hemostasis, Are Positively Associated with Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a Population-Based Cross-Sectional Study |
title_fullStr |
Thrombomodulin and Thrombopoietin, Two Biomarkers of Hemostasis, Are Positively Associated with Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a Population-Based Cross-Sectional Study |
title_full_unstemmed |
Thrombomodulin and Thrombopoietin, Two Biomarkers of Hemostasis, Are Positively Associated with Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a Population-Based Cross-Sectional Study |
title_sort |
thrombomodulin and thrombopoietin, two biomarkers of hemostasis, are positively associated with adherence to the world cancer research fund/american institute for cancer research recommendations for cancer prevention in a population-based cross-sectional study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-09-01 |
description |
A pro-coagulative state is related to increased risk of cardiovascular diseases but also certain cancers. Since experimental and smaller human studies suggest that diet, physical activity, and body weight may all affect coagulation, we evaluated associations between these lifestyle factors and hemostatic biomarkers in a population-based study. Cross-sectional baseline data from 2267 randomly selected participants of EPIC-Heidelberg (age range 35−65 years) was used. Fibrinogen, glycoprotein IIb/IIIa, P-selectin, thrombomodulin (TM), and thrombopoietin (TPO) were measured in baseline plasma samples. A score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations for cancer prevention was created. Associations between the WCRF/AICR score as well as its individual components and hemostatic biomarkers were analyzed by linear regression models. Multivariable-adjusted geometric means (95% confidence intervals) of TM and TPO were higher with greater adherence to the WCRF/AICR recommendations (TM, lowest vs. highest score category: 2.90 (2.7,3.1) vs. 3.10 (2.9,3.3) ng/mL, <i>p</i><sub>linear trend</sub> = 0.0001; TPO: 328 (302,356) vs. 348 (321,378) pg/mL, <i>p</i><sub>linear trend</sub> = 0.0007). These associations were driven by lower alcohol and meat consumption among persons with higher WCRF/AICR scores. Our results indicate that lifestyle factors favorably affect TM and TPO, two hemostatic factors implicated in chronic disease development. |
topic |
lifestyle coagulation thrombomodulin thrombopoietin fibrinogen cancer prevention WCRF/AICR recommendations |
url |
https://www.mdpi.com/2072-6643/11/9/2067 |
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