Gonadal toxicity of Hodgkin lymphoma treatment in adolescents and young males: issue relevance and ways of solve (literature review)

Gonadal toxicity of Hodgkin lymphoma treatment in adolescents and young males: issue relevance and ways of solve (literature review)

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Hodgkin`s Lymphoma (HL) is one of the most curable cancer disease. A half of all patients are young males under 35 years old. Gonadal toxicity is one of the most frequent late effects of HL therapy and associated with significant decrease in patient’s quality of life. In present article frequency an...

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Bibliographic Details
Main Authors: A. A. Vinokurov, S. R. Varfolomeeva, D. I. Tarusin
Format: Article
Language:Russian
Published: ABV-press 2014-07-01
Series:Onkogematologiâ
Subjects:
hodgkin lymphoma
alkylate drugs
gonadal toxicity
semen cryopreservation
Online Access:https://oncohematology.abvpress.ru/ongm/article/view/97
Description
Summary:Hodgkin`s Lymphoma (HL) is one of the most curable cancer disease. A half of all patients are young males under 35 years old. Gonadal toxicity is one of the most frequent late effects of HL therapy and associated with significant decrease in patient’s quality of life. In present article frequency and risk factors of gonadal toxicity in males with HL were summarized. It was shown that chemotherapy with alkylating agents and radiotherapy may lead to gonadal toxicity in significant number of patients. Current possibilities of semen cryopreservation before start of the treatment are discussed.
ISSN:1818-8346

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