In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products
This study aims to assess the in vitro activity of different samples of cefoperazone/sulbactam (CFP/SUL) against multidrug-resistant organisms (MDROs). Clinical isolates of extended-spectrum β-lactamase (ESBL)-<i>Escherichia coli</i>, ESBL-<i>Klebsiella pneumoniae</i>...
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doaj-3da3b66ed65c4a04b028baf6569df3c02020-11-25T02:39:21ZengMDPI AGAntibiotics2079-63822020-02-01927710.3390/antibiotics9020077antibiotics9020077In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam ProductsMing-Jen Sheu0Chi-Chung Chen1Ying-Chen Lu2Bo-An Su3Chun-Cheng Zhang4Shu-Shen Wang5Yin-Ching Chuang6Hung-Jen Tang7Chih-Cheng Lai8Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, Tainan 710, TaiwanDepartment of Medical Research; Chi Mei Medical Center; Tainan 710, TaiwanDepartment of Medical Research; Chi Mei Medical Center; Tainan 710, TaiwanDepartment of Internal Medicine, Chi Mei Medical Center, Tainan 710, TaiwanDepartment of Internal Medicine, Chi Mei Medical Center, Tainan 710, TaiwanDepartment of Internal Medicine, Chi Mei Medical Center, Tainan 710, TaiwanDepartment of Medicinal Chemistry, Chia Nan University of Pharmacy & Science, Tainan 717, TaiwanDepartment of Internal Medicine, Chi Mei Medical Center, Tainan 710, TaiwanDepartment of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan 710, TaiwanThis study aims to assess the in vitro activity of different samples of cefoperazone/sulbactam (CFP/SUL) against multidrug-resistant organisms (MDROs). Clinical isolates of extended-spectrum β-lactamase (ESBL)-<i>Escherichia coli</i>, ESBL-<i>Klebsiella pneumoniae</i>, carbapenem-resistant <i>Acinetobacter baumannii</i> (CR-AB), and carbapenem-resistant <i>Pseudomonas aeruginosa</i> (CR-PA) were collected. The minimum inhibitory concentration (MIC) and time-killing methods were used to assess and compare the in vitro activities of different samples of cefoperazone/sulbactam (CFP/SUL) against these MDROs. For ESBL-<i>E. coli</i>, ESBL-<i>K. pneumoniae</i>, and CR-PA, product C had smaller variations than product A and B (<i>p</i> < 0.05). For CR-AB, product B had the largest variation compared to the other two products (<i>p</i> < 0.05). In the time-killing studies, significant differences among the products when used at 16/16 µg/mL were noted for ESBL-<i>E. coli</i>, ESBL-<i>K. pneumoniae</i>, and CR-AB isolates. In conclusion, this study demonstrated the significantly different activity of different products of CFP/SUL against MDROs.https://www.mdpi.com/2079-6382/9/2/77cefoperazone/sulbactammultidrug-resistant organismantimicrobial activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming-Jen Sheu Chi-Chung Chen Ying-Chen Lu Bo-An Su Chun-Cheng Zhang Shu-Shen Wang Yin-Ching Chuang Hung-Jen Tang Chih-Cheng Lai |
spellingShingle |
Ming-Jen Sheu Chi-Chung Chen Ying-Chen Lu Bo-An Su Chun-Cheng Zhang Shu-Shen Wang Yin-Ching Chuang Hung-Jen Tang Chih-Cheng Lai In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products Antibiotics cefoperazone/sulbactam multidrug-resistant organism antimicrobial activity |
author_facet |
Ming-Jen Sheu Chi-Chung Chen Ying-Chen Lu Bo-An Su Chun-Cheng Zhang Shu-Shen Wang Yin-Ching Chuang Hung-Jen Tang Chih-Cheng Lai |
author_sort |
Ming-Jen Sheu |
title |
In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title_short |
In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title_full |
In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title_fullStr |
In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title_full_unstemmed |
In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title_sort |
in vitro antimicrobial activity of various cefoperazone/sulbactam products |
publisher |
MDPI AG |
series |
Antibiotics |
issn |
2079-6382 |
publishDate |
2020-02-01 |
description |
This study aims to assess the in vitro activity of different samples of cefoperazone/sulbactam (CFP/SUL) against multidrug-resistant organisms (MDROs). Clinical isolates of extended-spectrum β-lactamase (ESBL)-<i>Escherichia coli</i>, ESBL-<i>Klebsiella pneumoniae</i>, carbapenem-resistant <i>Acinetobacter baumannii</i> (CR-AB), and carbapenem-resistant <i>Pseudomonas aeruginosa</i> (CR-PA) were collected. The minimum inhibitory concentration (MIC) and time-killing methods were used to assess and compare the in vitro activities of different samples of cefoperazone/sulbactam (CFP/SUL) against these MDROs. For ESBL-<i>E. coli</i>, ESBL-<i>K. pneumoniae</i>, and CR-PA, product C had smaller variations than product A and B (<i>p</i> < 0.05). For CR-AB, product B had the largest variation compared to the other two products (<i>p</i> < 0.05). In the time-killing studies, significant differences among the products when used at 16/16 µg/mL were noted for ESBL-<i>E. coli</i>, ESBL-<i>K. pneumoniae</i>, and CR-AB isolates. In conclusion, this study demonstrated the significantly different activity of different products of CFP/SUL against MDROs. |
topic |
cefoperazone/sulbactam multidrug-resistant organism antimicrobial activity |
url |
https://www.mdpi.com/2079-6382/9/2/77 |
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