Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease
Lyme disease is a multisystem tick-borne transmissive disease with heterogeneous manifestations, frequently making the diagnosis difficult in clinical practice. Herein, we report a case of a 43-year-old female patient who presented with generalized lymphadenopathy requiring a further diagnostic eval...
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Termedia Publishing House
2019-02-01
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doaj-3da4547a45b547e6a5858b4abfa694bc2020-11-25T03:46:09ZengTermedia Publishing HouseRheumatology0034-62332084-98342019-02-01571596210.5114/reum.2019.8324235945Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme diseaseSvitlana SmiyanIgor GalaychukIgor ZhulkevychVolodymyr NykolyukRoman KomorovskySofiya GusakIvan BilozetskyLyme disease is a multisystem tick-borne transmissive disease with heterogeneous manifestations, frequently making the diagnosis difficult in clinical practice. Herein, we report a case of a 43-year-old female patient who presented with generalized lymphadenopathy requiring a further diagnostic evaluation towards lymphoma. The patient also had clinical signs of Sjögren’s syndrome. Lymph node excision with subsequent histological and immunohistochemical studies were performed. While light microscopy findings were suspicious for lymphoma, immunohistochemistry results were consistent with cortical and paracortical lymph node hyperplasia with no evidence of lymphoproliferative disorder. Further laboratory testing confirmed the presence of Lyme borreliosis. Effectiveness of the administered antibiotic therapy confirmed Borrelia burgdorferi infection. Interrelationships between Sjögren’s syndrome, lymphadenopathy and Lyme disease are discussed.https://www.termedia.pl/Sjogren-s-syndrome-and-lymphadenopathy-unraveling-the-diagnosis-of-Lyme-disease,18,35945,1,1.htmlsjögren’s syndrome lymphadenopathy borrelia burgdorferi lyme disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Svitlana Smiyan Igor Galaychuk Igor Zhulkevych Volodymyr Nykolyuk Roman Komorovsky Sofiya Gusak Ivan Bilozetsky |
spellingShingle |
Svitlana Smiyan Igor Galaychuk Igor Zhulkevych Volodymyr Nykolyuk Roman Komorovsky Sofiya Gusak Ivan Bilozetsky Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease Rheumatology sjögren’s syndrome lymphadenopathy borrelia burgdorferi lyme disease |
author_facet |
Svitlana Smiyan Igor Galaychuk Igor Zhulkevych Volodymyr Nykolyuk Roman Komorovsky Sofiya Gusak Ivan Bilozetsky |
author_sort |
Svitlana Smiyan |
title |
Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease |
title_short |
Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease |
title_full |
Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease |
title_fullStr |
Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease |
title_full_unstemmed |
Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease |
title_sort |
sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of lyme disease |
publisher |
Termedia Publishing House |
series |
Rheumatology |
issn |
0034-6233 2084-9834 |
publishDate |
2019-02-01 |
description |
Lyme disease is a multisystem tick-borne transmissive disease with heterogeneous manifestations, frequently making the diagnosis difficult in clinical practice. Herein, we report a case of a 43-year-old female patient who presented with generalized lymphadenopathy requiring a further diagnostic evaluation towards lymphoma. The patient also had clinical signs of Sjögren’s syndrome. Lymph node excision with subsequent histological and immunohistochemical studies were performed. While light microscopy findings were suspicious for lymphoma, immunohistochemistry results were consistent with cortical and paracortical lymph node hyperplasia with no evidence of lymphoproliferative disorder. Further laboratory testing confirmed the presence of Lyme borreliosis. Effectiveness of the administered antibiotic therapy confirmed Borrelia burgdorferi infection. Interrelationships between Sjögren’s syndrome, lymphadenopathy and Lyme disease are discussed. |
topic |
sjögren’s syndrome lymphadenopathy borrelia burgdorferi lyme disease |
url |
https://www.termedia.pl/Sjogren-s-syndrome-and-lymphadenopathy-unraveling-the-diagnosis-of-Lyme-disease,18,35945,1,1.html |
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