Functional identification of neuroprotective molecules.

Functional identification of neuroprotective molecules.

The central nervous system has the capacity to activate profound neuroprotection following sub-lethal stress in a process termed preconditioning. To gain insight into this potent survival response we developed a functional cloning strategy that identified 31 putative neuroprotective genes of which 2...

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Main Authors: Cheng Dai, Dong Liang, Huiwu Li, Masayuki Sasaki, Ted M Dawson, Valina L Dawson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2991347?pdf=render
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spelling doaj-3da4a4ab5da7445c8c06789d7a09f73f2020-11-24T20:51:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-11-01511e1500810.1371/journal.pone.0015008Functional identification of neuroprotective molecules.Cheng DaiDong LiangHuiwu LiMasayuki SasakiTed M DawsonValina L DawsonThe central nervous system has the capacity to activate profound neuroprotection following sub-lethal stress in a process termed preconditioning. To gain insight into this potent survival response we developed a functional cloning strategy that identified 31 putative neuroprotective genes of which 28 were confirmed to provide protection against oxygen-glucose deprivation (OGD) or excitotoxic exposure to N-methyl-D-aspartate (NMDA) in primary rat cortical neurons. These results reveal that the brain possesses a wide and diverse repertoire of neuroprotective genes. Further characterization of these and other protective signals could provide new treatment opportunities for neurological injury from ischemia or neurodegenerative disease.http://europepmc.org/articles/PMC2991347?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Cheng Dai
Dong Liang
Huiwu Li
Masayuki Sasaki
Ted M Dawson
Valina L Dawson
spellingShingle Cheng Dai
Dong Liang
Huiwu Li
Masayuki Sasaki
Ted M Dawson
Valina L Dawson
Functional identification of neuroprotective molecules.
PLoS ONE
author_facet Cheng Dai
Dong Liang
Huiwu Li
Masayuki Sasaki
Ted M Dawson
Valina L Dawson
author_sort Cheng Dai
title Functional identification of neuroprotective molecules.
title_short Functional identification of neuroprotective molecules.
title_full Functional identification of neuroprotective molecules.
title_fullStr Functional identification of neuroprotective molecules.
title_full_unstemmed Functional identification of neuroprotective molecules.
title_sort functional identification of neuroprotective molecules.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2010-11-01
description The central nervous system has the capacity to activate profound neuroprotection following sub-lethal stress in a process termed preconditioning. To gain insight into this potent survival response we developed a functional cloning strategy that identified 31 putative neuroprotective genes of which 28 were confirmed to provide protection against oxygen-glucose deprivation (OGD) or excitotoxic exposure to N-methyl-D-aspartate (NMDA) in primary rat cortical neurons. These results reveal that the brain possesses a wide and diverse repertoire of neuroprotective genes. Further characterization of these and other protective signals could provide new treatment opportunities for neurological injury from ischemia or neurodegenerative disease.
url http://europepmc.org/articles/PMC2991347?pdf=render
work_keys_str_mv AT chengdai functionalidentificationofneuroprotectivemolecules
AT dongliang functionalidentificationofneuroprotectivemolecules
AT huiwuli functionalidentificationofneuroprotectivemolecules
AT masayukisasaki functionalidentificationofneuroprotectivemolecules
AT tedmdawson functionalidentificationofneuroprotectivemolecules
AT valinaldawson functionalidentificationofneuroprotectivemolecules
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