Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer
The crosstalk between cancer cells and host cells is a crucial prerequisite for tumor growth and progression. The cells from both the innate and adaptive immune systems enter into a perverse relationship with tumor cells to create a tumor-promoting and immunosuppressive tumor microenvironment (TME)....
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doaj-3daaac085cce415986da8cc778c82dbe2020-11-24T23:30:43ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-02-0120489010.3390/ijms20040890ijms20040890Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian CancerMarco Greppi0Giovanna Tabellini1Ornella Patrizi2Simona Candiani3Andrea Decensi4Silvia Parolini5Simona Sivori6Silvia Pesce7Laura Paleari8Emanuela Marcenaro9Department of Experimental Medicine (DIMES) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Earth Science, Environment and Life (DISTAV), University of Genoa, 16132 Genoa, ItalyDivision of Medical Oncology, Galliera Hospital, 16126 Genoa, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Experimental Medicine (DIMES) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, ItalyDepartment of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, ItalyA.Li.Sa., Liguria Health Authority, 16121 Genoa, ItalyDepartment of Experimental Medicine (DIMES) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, ItalyThe crosstalk between cancer cells and host cells is a crucial prerequisite for tumor growth and progression. The cells from both the innate and adaptive immune systems enter into a perverse relationship with tumor cells to create a tumor-promoting and immunosuppressive tumor microenvironment (TME). Epithelial ovarian cancer (EOC), the most lethal of all gynecological malignancies, is characterized by a unique TME that paves the way to the formation of metastasis and mediates therapy resistance through the deregulation of immune surveillance. A characteristic feature of the ovarian cancer TME is the ascites/peritoneal fluid, a malignancy-associated effusion occurring at more advanced stages, which enables the peritoneal dissemination of tumor cells and the formation of metastasis. The standard therapy for EOC involves a combination of debulking surgery and platinum-based chemotherapy. However, most patients experience disease recurrence. New therapeutic strategies are needed to improve the prognosis of patients with advanced EOC. Harnessing the body’s natural immune defenses against cancer in the form of immunotherapy is emerging as an innovative treatment strategy. NK cells have attracted attention as a promising cancer immunotherapeutic target due to their ability to kill malignant cells and avoid healthy cells. Here, we will discuss the recent advances in the clinical application of NK cell immunotherapy in EOC.https://www.mdpi.com/1422-0067/20/4/890ovarian cancerNK cellsimmunotherapyimmune checkpointPD-1activating receptorsB7-H6antitumor activityhormone therapyadoptive therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marco Greppi Giovanna Tabellini Ornella Patrizi Simona Candiani Andrea Decensi Silvia Parolini Simona Sivori Silvia Pesce Laura Paleari Emanuela Marcenaro |
spellingShingle |
Marco Greppi Giovanna Tabellini Ornella Patrizi Simona Candiani Andrea Decensi Silvia Parolini Simona Sivori Silvia Pesce Laura Paleari Emanuela Marcenaro Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer International Journal of Molecular Sciences ovarian cancer NK cells immunotherapy immune checkpoint PD-1 activating receptors B7-H6 antitumor activity hormone therapy adoptive therapy |
author_facet |
Marco Greppi Giovanna Tabellini Ornella Patrizi Simona Candiani Andrea Decensi Silvia Parolini Simona Sivori Silvia Pesce Laura Paleari Emanuela Marcenaro |
author_sort |
Marco Greppi |
title |
Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer |
title_short |
Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer |
title_full |
Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer |
title_fullStr |
Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer |
title_full_unstemmed |
Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer |
title_sort |
strengthening the antitumor nk cell function for the treatment of ovarian cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-02-01 |
description |
The crosstalk between cancer cells and host cells is a crucial prerequisite for tumor growth and progression. The cells from both the innate and adaptive immune systems enter into a perverse relationship with tumor cells to create a tumor-promoting and immunosuppressive tumor microenvironment (TME). Epithelial ovarian cancer (EOC), the most lethal of all gynecological malignancies, is characterized by a unique TME that paves the way to the formation of metastasis and mediates therapy resistance through the deregulation of immune surveillance. A characteristic feature of the ovarian cancer TME is the ascites/peritoneal fluid, a malignancy-associated effusion occurring at more advanced stages, which enables the peritoneal dissemination of tumor cells and the formation of metastasis. The standard therapy for EOC involves a combination of debulking surgery and platinum-based chemotherapy. However, most patients experience disease recurrence. New therapeutic strategies are needed to improve the prognosis of patients with advanced EOC. Harnessing the body’s natural immune defenses against cancer in the form of immunotherapy is emerging as an innovative treatment strategy. NK cells have attracted attention as a promising cancer immunotherapeutic target due to their ability to kill malignant cells and avoid healthy cells. Here, we will discuss the recent advances in the clinical application of NK cell immunotherapy in EOC. |
topic |
ovarian cancer NK cells immunotherapy immune checkpoint PD-1 activating receptors B7-H6 antitumor activity hormone therapy adoptive therapy |
url |
https://www.mdpi.com/1422-0067/20/4/890 |
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