Virulence Factors in Hypervirulent Klebsiella pneumoniae

Virulence Factors in Hypervirulent Klebsiella pneumoniae

Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver ab...

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Main Authors: Jie Zhu, Tao Wang, Liang Chen, Hong Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Microbiology
Subjects:
Klebsiella pneumoniae
hypermucoviscous
capsule
siderophores
virulence factors
hypervirulence
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.642484/full
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spelling doaj-3db45f5a4b4e4ac7ad926aa5672183d32021-04-08T05:20:19ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-04-011210.3389/fmicb.2021.642484642484Virulence Factors in Hypervirulent Klebsiella pneumoniaeJie Zhu0Tao Wang1Liang Chen2Liang Chen3Hong Du4Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaHackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ, United StatesDepartment of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, NJ, United StatesDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaHypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver abscess, pneumonia, meningitis, and endophthalmitis. It utilizes a battery of virulence factors for survival and pathogenesis, such as capsule, siderophores, lipopolysaccharide, fimbriae, outer membrane proteins, and type 6 secretion system, of which the former two are dominant. This review summarizes these hvKP-associated virulence factors in order to understand its molecular pathogenesis and shed light on new strategies to improve the prevention, diagnosis, and treatment of hvKP-causing infection.https://www.frontiersin.org/articles/10.3389/fmicb.2021.642484/fullKlebsiella pneumoniaehypermucoviscouscapsulesiderophoresvirulence factorshypervirulence
collection DOAJ
language English
format Article
sources DOAJ
author Jie Zhu
Tao Wang
Liang Chen
Liang Chen
Hong Du
spellingShingle Jie Zhu
Tao Wang
Liang Chen
Liang Chen
Hong Du
Virulence Factors in Hypervirulent Klebsiella pneumoniae
Frontiers in Microbiology
Klebsiella pneumoniae
hypermucoviscous
capsule
siderophores
virulence factors
hypervirulence
author_facet Jie Zhu
Tao Wang
Liang Chen
Liang Chen
Hong Du
author_sort Jie Zhu
title Virulence Factors in Hypervirulent Klebsiella pneumoniae
title_short Virulence Factors in Hypervirulent Klebsiella pneumoniae
title_full Virulence Factors in Hypervirulent Klebsiella pneumoniae
title_fullStr Virulence Factors in Hypervirulent Klebsiella pneumoniae
title_full_unstemmed Virulence Factors in Hypervirulent Klebsiella pneumoniae
title_sort virulence factors in hypervirulent klebsiella pneumoniae
publisher Frontiers Media S.A.
series Frontiers in Microbiology
issn 1664-302X
publishDate 2021-04-01
description Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver abscess, pneumonia, meningitis, and endophthalmitis. It utilizes a battery of virulence factors for survival and pathogenesis, such as capsule, siderophores, lipopolysaccharide, fimbriae, outer membrane proteins, and type 6 secretion system, of which the former two are dominant. This review summarizes these hvKP-associated virulence factors in order to understand its molecular pathogenesis and shed light on new strategies to improve the prevention, diagnosis, and treatment of hvKP-causing infection.
topic Klebsiella pneumoniae
hypermucoviscous
capsule
siderophores
virulence factors
hypervirulence
url https://www.frontiersin.org/articles/10.3389/fmicb.2021.642484/full
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