<em>N</em>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H</em>)-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella </em>(L.) and SAR Study

<em>N</em>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H</em>)-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella </em>(L.) and SAR Study

A series of <em>N</em>-substituted 5-chloro-6-phenylpyridazin-3(2<em>H</em>)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for <em>in vitro</em&...

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Main Authors: Song Yang, Qingcai Shi, Qinkun Yuan, Lijun Luo, Juan Ma, Jian Wu, Shenghong Kang
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:Molecules
Subjects:
pridazin-3(2<em>H</em>)-one
synthesis
insecticidal activity
SAR study
<em>Plutella </em><em>xylostella</em>
Online Access:http://www.mdpi.com/1420-3049/17/8/9413
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spelling doaj-3db6eb3b0ff245219be171090ba3bb472020-11-24T23:38:42ZengMDPI AGMolecules1420-30492012-08-011789413942010.3390/molecules17089413<em>N</em>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H</em>)-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella </em>(L.) and SAR StudySong YangQingcai ShiQinkun YuanLijun LuoJuan MaJian WuShenghong KangA series of <em>N</em>-substituted 5-chloro-6-phenylpyridazin-3(2<em>H</em>)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for <em>in vitro</em> insecticidal activity against <em>Plutella xylostella</em>. The results showed that the synthesized pyridazin-3(2<em>H</em>)-one compounds possessed good insecticidal activities, especially the compounds <strong>4b</strong>, <strong>4d</strong>, and <strong>4h </strong>which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.http://www.mdpi.com/1420-3049/17/8/9413pridazin-3(2<em>H</em>)-onesynthesisinsecticidal activitySAR study<em>Plutella </em><em>xylostella</em>
collection DOAJ
language English
format Article
sources DOAJ
author Song Yang
Qingcai Shi
Qinkun Yuan
Lijun Luo
Juan Ma
Jian Wu
Shenghong Kang
spellingShingle Song Yang
Qingcai Shi
Qinkun Yuan
Lijun Luo
Juan Ma
Jian Wu
Shenghong Kang
<em>N</em>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H</em>)-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella </em>(L.) and SAR Study
Molecules
pridazin-3(2<em>H</em>)-one
synthesis
insecticidal activity
SAR study
<em>Plutella </em><em>xylostella</em>
author_facet Song Yang
Qingcai Shi
Qinkun Yuan
Lijun Luo
Juan Ma
Jian Wu
Shenghong Kang
author_sort Song Yang
title <em>N</em>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H</em>)-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella </em>(L.) and SAR Study
title_short <em>N</em>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H</em>)-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella </em>(L.) and SAR Study
title_full <em>N</em>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H</em>)-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella </em>(L.) and SAR Study
title_fullStr <em>N</em>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H</em>)-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella </em>(L.) and SAR Study
title_full_unstemmed <em>N</em>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H</em>)-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella </em>(L.) and SAR Study
title_sort <em>n</em>-substituted 5-chloro-6-phenylpyridazin-3(2<em>h</em>)-ones: synthesis, insecticidal activity against <em>plutella xylostella </em>(l.) and sar study
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2012-08-01
description A series of <em>N</em>-substituted 5-chloro-6-phenylpyridazin-3(2<em>H</em>)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for <em>in vitro</em> insecticidal activity against <em>Plutella xylostella</em>. The results showed that the synthesized pyridazin-3(2<em>H</em>)-one compounds possessed good insecticidal activities, especially the compounds <strong>4b</strong>, <strong>4d</strong>, and <strong>4h </strong>which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.
topic pridazin-3(2<em>H</em>)-one
synthesis
insecticidal activity
SAR study
<em>Plutella </em><em>xylostella</em>
url http://www.mdpi.com/1420-3049/17/8/9413
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