Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease

Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease

The Grb-2 associated binder (Gab) family of scaffolding/adaptor/docking proteins is a group of three molecules with significant roles in cytokine receptor signaling. Gabs possess structural motifs for phosphorylation-dependent receptor recruitment, Grb2 binding, and activation of downstream signalin...

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Bibliographic Details
Main Authors:	Sheetal Verma, Tamisha Vaughan, Kevin D. Bunting
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Advances in Hematology
Online Access:	http://dx.doi.org/10.1155/2012/380635

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