Structural-Based Optimizations of the Marine-Originated Meridianin C as Glucose Uptake Agents by Inhibiting GSK-3β

Structural-Based Optimizations of the Marine-Originated Meridianin C as Glucose Uptake Agents by Inhibiting GSK-3β

Glycogen synthase kinase 3β (GSK-3β) is a widely investigated molecular target for numerous diseases, and inhibition of GSK-3β activity has become an attractive approach for the treatment of diabetes. Meridianin C, an indole-based natural product isolated from marine <i>Aplidium meridianum<...

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Bibliographic Details
Main Authors: Shuwen Han, Chunlin Zhuang, Wei Zhou, Fener Chen
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Marine Drugs
Subjects:
glycogen synthase kinase 3β
inhibitor
structural-based optimization
diabetes
glucose uptake
Online Access:https://www.mdpi.com/1660-3397/19/3/149

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