The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma
Background: Acromegaly defines as chronic elevations of insulin-like growth factor-1 (IGF-1) and growth hormone (GH), which results in enlargement of organs and soft tissues. Cardiovascular complications of acromegaly such as cardiomegaly, hypertension contributing to a high risk of cardiovascular e...
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doaj-3dbd2aff1a4e4e39b8a7b633186b107a2020-11-25T01:31:19ZengShahid Beheshti University of Medical SciencesInternational Clinical Neuroscience Journal2383-18712383-20962020-01-0171313410.15171/icnj.2020.05icnj-4153The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary AdenomaKaveh Ebrahimzadeh0Kurosh Mojtabavi1Sasan Mohammadi2Mehrdad Farahani3Zohreh Gholizadeh Ghozloujeh4Sina Asaadi5Guive Sharifi6Mohammad Amin Joshaghanian7Omidvar Rezaei8Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranCellular and Molecular Research Center & Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran IranDivision of Vascular and Endovascular Neurosurgery, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran IranSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: Acromegaly defines as chronic elevations of insulin-like growth factor-1 (IGF-1) and growth hormone (GH), which results in enlargement of organs and soft tissues. Cardiovascular complications of acromegaly such as cardiomegaly, hypertension contributing to a high risk of cardiovascular events. This study aimed to identify the determinants of the prevalence of cardiomegaly as cardiovascular comorbidity of acromegaly and the potential effect of the curative intervention. Methods: A total of 160 patients with acromegaly due to pituitary adenoma participated in this study. Acromegaly diagnosed was based on clinical manifestations, age-adjusted plasma IGF-I, and elevated plasma GH levels, not suppressible during an oral glucose tolerance test (75 g). Electrocardiogram and chest X-ray obtained in all patients. Treatment approaches included transsphenoidal surgery and hormonal evaluation performed before and six months after surgery. Results: The GH serum level was elevated in all patients before surgery, with a mean of 33.7 ng/ mL that reached 5.7 ng/mL after surgery. Mean IGF-1 was 794.1 ng/mL that reached 395.6 ng/mL postoperatively. The prevalence of cardiomegaly was 15% that improved in 5% of patients after trans sphenoidal surgery. Conclusion: Appropriate surgical intervention in acromegaly that complicated by cardiomegaly may result in significant improvement of the cardiac structure.http://journals.sbmu.ac.ir/Neuroscience/article/download/27303/5acromegalypituitary adenomatranssphenoidal surgerycardiomegaly |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kaveh Ebrahimzadeh Kurosh Mojtabavi Sasan Mohammadi Mehrdad Farahani Zohreh Gholizadeh Ghozloujeh Sina Asaadi Guive Sharifi Mohammad Amin Joshaghanian Omidvar Rezaei |
spellingShingle |
Kaveh Ebrahimzadeh Kurosh Mojtabavi Sasan Mohammadi Mehrdad Farahani Zohreh Gholizadeh Ghozloujeh Sina Asaadi Guive Sharifi Mohammad Amin Joshaghanian Omidvar Rezaei The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma International Clinical Neuroscience Journal acromegaly pituitary adenoma transsphenoidal surgery cardiomegaly |
author_facet |
Kaveh Ebrahimzadeh Kurosh Mojtabavi Sasan Mohammadi Mehrdad Farahani Zohreh Gholizadeh Ghozloujeh Sina Asaadi Guive Sharifi Mohammad Amin Joshaghanian Omidvar Rezaei |
author_sort |
Kaveh Ebrahimzadeh |
title |
The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma |
title_short |
The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma |
title_full |
The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma |
title_fullStr |
The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma |
title_full_unstemmed |
The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma |
title_sort |
therapeutic effect of endoscopic tumor resection on acromegalic cardiomegaly in patients with pituitary adenoma |
publisher |
Shahid Beheshti University of Medical Sciences |
series |
International Clinical Neuroscience Journal |
issn |
2383-1871 2383-2096 |
publishDate |
2020-01-01 |
description |
Background: Acromegaly defines as chronic elevations of insulin-like growth factor-1 (IGF-1) and growth hormone (GH), which results in enlargement of organs and soft tissues. Cardiovascular complications of acromegaly such as cardiomegaly, hypertension contributing to a high risk of cardiovascular events. This study aimed to identify the determinants of the prevalence of cardiomegaly as cardiovascular comorbidity of acromegaly and the potential effect of the curative intervention. Methods: A total of 160 patients with acromegaly due to pituitary adenoma participated in this study. Acromegaly diagnosed was based on clinical manifestations, age-adjusted plasma IGF-I, and elevated plasma GH levels, not suppressible during an oral glucose tolerance test (75 g). Electrocardiogram and chest X-ray obtained in all patients. Treatment approaches included transsphenoidal surgery and hormonal evaluation performed before and six months after surgery. Results: The GH serum level was elevated in all patients before surgery, with a mean of 33.7 ng/ mL that reached 5.7 ng/mL after surgery. Mean IGF-1 was 794.1 ng/mL that reached 395.6 ng/mL postoperatively. The prevalence of cardiomegaly was 15% that improved in 5% of patients after trans sphenoidal surgery. Conclusion: Appropriate surgical intervention in acromegaly that complicated by cardiomegaly may result in significant improvement of the cardiac structure. |
topic |
acromegaly pituitary adenoma transsphenoidal surgery cardiomegaly |
url |
http://journals.sbmu.ac.ir/Neuroscience/article/download/27303/5 |
work_keys_str_mv |
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