ABCA1 influences neuroinflammation and neuronal death

ABCA1 influences neuroinflammation and neuronal death

ATP-binding cassette transporter A1 (ABCA1) mediates cellular cholesterol efflux in the brain and influences whole brain cholesterol homeostasis. Activation of liver X receptors (LXRs), transcription factors that increase the expression of cholesterol transport genes including ABCA1, reduces neuroin...

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Bibliographic Details
Main Authors: Joanna M. Karasinska, Willeke de Haan, Sonia Franciosi, Piers Ruddle, Jianjia Fan, Janine K. Kruit, Sophie Stukas, Dieter Lütjohann, David H. Gutmann, Cheryl L. Wellington, Michael R. Hayden
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
Brain cholesterol metabolism
ABCA1
Apolipoproteins
Neuroinflammation
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000429

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