The Many Faces of Rap1 GTPase
This review addresses the issue of the numerous roles played by Rap1 GTPase (guanosine triphosphatase) in different cell types, in terms of both physiology and pathology. It is one among a myriad of small G proteins with endogenous GTP-hydrolyzing activity that is considerably stimulated by posttran...
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doaj-3dc3e443beec4e5bb9cbf4d3c707708f2020-11-25T00:54:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-09-011910284810.3390/ijms19102848ijms19102848The Many Faces of Rap1 GTPaseAnna Jaśkiewicz0Beata Pająk1Arkadiusz Orzechowski2Department of Physiological Sciences, Warsaw University of Life Sciences—SGGW, Nowoursynowska 159, 02-776 Warsaw, PolandIndependent Laboratory of Genetics and Molecular Biology, Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, PolandDepartment of Physiological Sciences, Warsaw University of Life Sciences—SGGW, Nowoursynowska 159, 02-776 Warsaw, PolandThis review addresses the issue of the numerous roles played by Rap1 GTPase (guanosine triphosphatase) in different cell types, in terms of both physiology and pathology. It is one among a myriad of small G proteins with endogenous GTP-hydrolyzing activity that is considerably stimulated by posttranslational modifications (geranylgeranylation) or guanine nucleotide exchange factors (GEFs), and inhibited by GTPase-activating proteins (GAPs). Rap1 is a ubiquitous protein that plays an essential role in the control of metabolic processes, such as signal transduction from plasma membrane receptors, cytoskeleton rearrangements necessary for cell division, intracellular and substratum adhesion, as well as cell motility, which is needed for extravasation or fusion. We present several examples of how Rap1 affects cells and organs, pointing to possible molecular manipulations that could have application in the therapy of several diseases.http://www.mdpi.com/1422-0067/19/10/2848Rap1 GTPaseguanine nucleotide exchange factors (GEFs)GTPase-activating proteins (GAPs)isoprenylationgeranylgeraniol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna Jaśkiewicz Beata Pająk Arkadiusz Orzechowski |
spellingShingle |
Anna Jaśkiewicz Beata Pająk Arkadiusz Orzechowski The Many Faces of Rap1 GTPase International Journal of Molecular Sciences Rap1 GTPase guanine nucleotide exchange factors (GEFs) GTPase-activating proteins (GAPs) isoprenylation geranylgeraniol |
author_facet |
Anna Jaśkiewicz Beata Pająk Arkadiusz Orzechowski |
author_sort |
Anna Jaśkiewicz |
title |
The Many Faces of Rap1 GTPase |
title_short |
The Many Faces of Rap1 GTPase |
title_full |
The Many Faces of Rap1 GTPase |
title_fullStr |
The Many Faces of Rap1 GTPase |
title_full_unstemmed |
The Many Faces of Rap1 GTPase |
title_sort |
many faces of rap1 gtpase |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-09-01 |
description |
This review addresses the issue of the numerous roles played by Rap1 GTPase (guanosine triphosphatase) in different cell types, in terms of both physiology and pathology. It is one among a myriad of small G proteins with endogenous GTP-hydrolyzing activity that is considerably stimulated by posttranslational modifications (geranylgeranylation) or guanine nucleotide exchange factors (GEFs), and inhibited by GTPase-activating proteins (GAPs). Rap1 is a ubiquitous protein that plays an essential role in the control of metabolic processes, such as signal transduction from plasma membrane receptors, cytoskeleton rearrangements necessary for cell division, intracellular and substratum adhesion, as well as cell motility, which is needed for extravasation or fusion. We present several examples of how Rap1 affects cells and organs, pointing to possible molecular manipulations that could have application in the therapy of several diseases. |
topic |
Rap1 GTPase guanine nucleotide exchange factors (GEFs) GTPase-activating proteins (GAPs) isoprenylation geranylgeraniol |
url |
http://www.mdpi.com/1422-0067/19/10/2848 |
work_keys_str_mv |
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