The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

Prostate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In this review, we focused on studies that demonstrated anticancer effects of cannabinoids and their po...

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Main Authors: Kanika Singh, Nazim Nassar, Ava Bachari, Ellen Schanknecht, Srinivasareddy Telukutla, Roby Zomer, Terrence J. Piva, Nitin Mantri
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
prostate cancer
cannabis
cannabinoids
cannabinoid receptors
cancer
Online Access:https://www.mdpi.com/2072-6694/13/16/4107
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spelling doaj-3dc4250e8c224e589f0622b15821257f2021-08-26T13:35:50ZengMDPI AGCancers2072-66942021-08-01134107410710.3390/cancers13164107The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate CancerKanika Singh0Nazim Nassar1Ava Bachari2Ellen Schanknecht3Srinivasareddy Telukutla4Roby Zomer5Terrence J. Piva6Nitin Mantri7The Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, AustraliaSchool of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, AustraliaThe Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, AustraliaThe Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, AustraliaThe Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, AustraliaMGC Pharmaceuticals Limited, West Perth, WA 6005, AustraliaSchool of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, AustraliaThe Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, AustraliaProstate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In this review, we focused on studies that demonstrated anticancer effects of cannabinoids and their possible mechanisms of action in prostate cancer. Besides the palliative effects of cannabinoids, research from the past two decades has demonstrated their promising potential as antitumor agents in a wide variety of cancers. This analysis may provide pharmacological insights into the selection of specific cannabinoids for the development of antitumor drugs for the treatment of prostate cancer.https://www.mdpi.com/2072-6694/13/16/4107prostate cancercannabiscannabinoidscannabinoid receptorscancer
collection DOAJ
language English
format Article
sources DOAJ
author Kanika Singh
Nazim Nassar
Ava Bachari
Ellen Schanknecht
Srinivasareddy Telukutla
Roby Zomer
Terrence J. Piva
Nitin Mantri
spellingShingle Kanika Singh
Nazim Nassar
Ava Bachari
Ellen Schanknecht
Srinivasareddy Telukutla
Roby Zomer
Terrence J. Piva
Nitin Mantri
The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer
Cancers
prostate cancer
cannabis
cannabinoids
cannabinoid receptors
cancer
author_facet Kanika Singh
Nazim Nassar
Ava Bachari
Ellen Schanknecht
Srinivasareddy Telukutla
Roby Zomer
Terrence J. Piva
Nitin Mantri
author_sort Kanika Singh
title The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer
title_short The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer
title_full The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer
title_fullStr The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer
title_full_unstemmed The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer
title_sort pathophysiology and the therapeutic potential of cannabinoids in prostate cancer
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2021-08-01
description Prostate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In this review, we focused on studies that demonstrated anticancer effects of cannabinoids and their possible mechanisms of action in prostate cancer. Besides the palliative effects of cannabinoids, research from the past two decades has demonstrated their promising potential as antitumor agents in a wide variety of cancers. This analysis may provide pharmacological insights into the selection of specific cannabinoids for the development of antitumor drugs for the treatment of prostate cancer.
topic prostate cancer
cannabis
cannabinoids
cannabinoid receptors
cancer
url https://www.mdpi.com/2072-6694/13/16/4107
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