Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation
Abstract Hypoxia is the major influence factor in physiological and pathological courses which are mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions within solid tumors. Under normoxia, HIF signaling pathway is inhibited due to HIF-α subunits degradation. However...
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doaj-3dc64a595d5a44a6be5538d4e2133c8f2020-11-25T03:58:21ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662020-10-0139112510.1186/s13046-020-01733-5Epigenetic crosstalk between hypoxia and tumor driven by HIF regulationTiansheng Li0Chao Mao1Xiang Wang2Ying Shi3Yongguang Tao4NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityNHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityDepartment of Thoracic Surgery, Second Xiangya Hospital, Central South UniversityNHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityNHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityAbstract Hypoxia is the major influence factor in physiological and pathological courses which are mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions within solid tumors. Under normoxia, HIF signaling pathway is inhibited due to HIF-α subunits degradation. However, in hypoxic conditions, HIF-α is activated and stabilized, and HIF target genes are successively activated, resulting in a series of tumour-specific activities. The activation of HIFs, including HIF-1α, HIF-2α and HIF-3α, subsequently induce downstream target genes which leads to series of responses, the resulting abnormal processes or metabolites in turn affect HIFs stability. Given its functions in tumors progression, HIFs have been regarded as therapeutic targets for improved treatment efficacy. Epigenetics refers to alterations in gene expression that are stable between cell divisions, and sometimes between generations, but do not involve changes in the underlying DNA sequence of the organism. And with the development of research, epigenetic regulation has been found to play an important role in the development of tumors, which providing accumulating basic or clinical evidences for tumor treatments. Here, given how little has been reported about the overall association between hypoxic tumors and epigenetics, we made a more systematic review from epigenetic perspective in hope of helping others better understand hypoxia or HIF pathway, and providing more established and potential therapeutic strategies in tumors to facilitate epigenetic studies of tumors.http://link.springer.com/article/10.1186/s13046-020-01733-5HypoxiaHypoxia-inducible factors (HIFs)TumorsEpigenetic regulationCrosstalkTherapeutic strategy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tiansheng Li Chao Mao Xiang Wang Ying Shi Yongguang Tao |
spellingShingle |
Tiansheng Li Chao Mao Xiang Wang Ying Shi Yongguang Tao Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation Journal of Experimental & Clinical Cancer Research Hypoxia Hypoxia-inducible factors (HIFs) Tumors Epigenetic regulation Crosstalk Therapeutic strategy |
author_facet |
Tiansheng Li Chao Mao Xiang Wang Ying Shi Yongguang Tao |
author_sort |
Tiansheng Li |
title |
Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation |
title_short |
Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation |
title_full |
Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation |
title_fullStr |
Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation |
title_full_unstemmed |
Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation |
title_sort |
epigenetic crosstalk between hypoxia and tumor driven by hif regulation |
publisher |
BMC |
series |
Journal of Experimental & Clinical Cancer Research |
issn |
1756-9966 |
publishDate |
2020-10-01 |
description |
Abstract Hypoxia is the major influence factor in physiological and pathological courses which are mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions within solid tumors. Under normoxia, HIF signaling pathway is inhibited due to HIF-α subunits degradation. However, in hypoxic conditions, HIF-α is activated and stabilized, and HIF target genes are successively activated, resulting in a series of tumour-specific activities. The activation of HIFs, including HIF-1α, HIF-2α and HIF-3α, subsequently induce downstream target genes which leads to series of responses, the resulting abnormal processes or metabolites in turn affect HIFs stability. Given its functions in tumors progression, HIFs have been regarded as therapeutic targets for improved treatment efficacy. Epigenetics refers to alterations in gene expression that are stable between cell divisions, and sometimes between generations, but do not involve changes in the underlying DNA sequence of the organism. And with the development of research, epigenetic regulation has been found to play an important role in the development of tumors, which providing accumulating basic or clinical evidences for tumor treatments. Here, given how little has been reported about the overall association between hypoxic tumors and epigenetics, we made a more systematic review from epigenetic perspective in hope of helping others better understand hypoxia or HIF pathway, and providing more established and potential therapeutic strategies in tumors to facilitate epigenetic studies of tumors. |
topic |
Hypoxia Hypoxia-inducible factors (HIFs) Tumors Epigenetic regulation Crosstalk Therapeutic strategy |
url |
http://link.springer.com/article/10.1186/s13046-020-01733-5 |
work_keys_str_mv |
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1724457697496006656 |