An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate
OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.
Bibliographic Details
| Main Authors: |
Jamie Zagozewski,
Ghazaleh M. Shahriary,
Ludivine Coudière Morrison,
Olivier Saulnier,
Margaret Stromecki,
Agnes Fresnoza,
Gareth Palidwor,
Christopher J. Porter,
Antoine Forget,
Olivier Ayrault,
Cynthia Hawkins,
Jennifer A. Chan,
Maria C. Vladoiu,
Lakshmikirupa Sundaresan,
Janilyn Arsenio,
Michael D. Taylor,
Vijay Ramaswamy,
Tamra E. Werbowetski-Ogilvie |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-17357-4
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