Depression at Treatment Initiation Predicts HIV Antiretroviral Adherence in Uganda
We examined the relationship between depression (symptom type, diagnostic severity, and change over time) and adherence to HIV antiretroviral therapy (ART) with data from 3 longitudinal studies (N = 1021) of patients starting ART in Uganda. The Patient Health Questionnaire was used to assess depress...
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doaj-3dc98fae73b14cf0bf341e96dab359482020-11-25T03:19:22ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95742325-95822017-01-011610.1177/2325957416677121Depression at Treatment Initiation Predicts HIV Antiretroviral Adherence in UgandaGlenn J. Wagner PhD0Mary Slaughter MS1Bonnie Ghosh-Dastidar PhD2 RAND Corporation, Santa Monica, CA, USA RAND Corporation, Santa Monica, CA, USA RAND Corporation, Santa Monica, CA, USAWe examined the relationship between depression (symptom type, diagnostic severity, and change over time) and adherence to HIV antiretroviral therapy (ART) with data from 3 longitudinal studies (N = 1021) of patients starting ART in Uganda. The Patient Health Questionnaire was used to assess depressive symptoms (total score; somatic and cognitive subscales) and categorize severity level. At baseline, 9% had major depression and 30% had minor depression; 82% were adherent (reported no missed ART doses in the past 7 days) at month 6 and 85% at month 12. Controlling for demographic and medical covariates, multivariate random-effects logistic regression models revealed that change in depression was not related to adherence; however, baseline total depression symptoms and cognitive symptoms in particular as well as major and minor depression were significant predictors of adherence. These findings highlight the need for early identification and aggressive treatment of depression to optimize ART adherence.https://doi.org/10.1177/2325957416677121 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Glenn J. Wagner PhD Mary Slaughter MS Bonnie Ghosh-Dastidar PhD |
spellingShingle |
Glenn J. Wagner PhD Mary Slaughter MS Bonnie Ghosh-Dastidar PhD Depression at Treatment Initiation Predicts HIV Antiretroviral Adherence in Uganda Journal of the International Association of Providers of AIDS Care |
author_facet |
Glenn J. Wagner PhD Mary Slaughter MS Bonnie Ghosh-Dastidar PhD |
author_sort |
Glenn J. Wagner PhD |
title |
Depression at Treatment Initiation Predicts HIV Antiretroviral Adherence in Uganda |
title_short |
Depression at Treatment Initiation Predicts HIV Antiretroviral Adherence in Uganda |
title_full |
Depression at Treatment Initiation Predicts HIV Antiretroviral Adherence in Uganda |
title_fullStr |
Depression at Treatment Initiation Predicts HIV Antiretroviral Adherence in Uganda |
title_full_unstemmed |
Depression at Treatment Initiation Predicts HIV Antiretroviral Adherence in Uganda |
title_sort |
depression at treatment initiation predicts hiv antiretroviral adherence in uganda |
publisher |
SAGE Publishing |
series |
Journal of the International Association of Providers of AIDS Care |
issn |
2325-9574 2325-9582 |
publishDate |
2017-01-01 |
description |
We examined the relationship between depression (symptom type, diagnostic severity, and change over time) and adherence to HIV antiretroviral therapy (ART) with data from 3 longitudinal studies (N = 1021) of patients starting ART in Uganda. The Patient Health Questionnaire was used to assess depressive symptoms (total score; somatic and cognitive subscales) and categorize severity level. At baseline, 9% had major depression and 30% had minor depression; 82% were adherent (reported no missed ART doses in the past 7 days) at month 6 and 85% at month 12. Controlling for demographic and medical covariates, multivariate random-effects logistic regression models revealed that change in depression was not related to adherence; however, baseline total depression symptoms and cognitive symptoms in particular as well as major and minor depression were significant predictors of adherence. These findings highlight the need for early identification and aggressive treatment of depression to optimize ART adherence. |
url |
https://doi.org/10.1177/2325957416677121 |
work_keys_str_mv |
AT glennjwagnerphd depressionattreatmentinitiationpredictshivantiretroviraladherenceinuganda AT maryslaughterms depressionattreatmentinitiationpredictshivantiretroviraladherenceinuganda AT bonnieghoshdastidarphd depressionattreatmentinitiationpredictshivantiretroviraladherenceinuganda |
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