Live imaging and tracking of genome regions in CRISPR/dCas9 knock-in mice

Live imaging and tracking of genome regions in CRISPR/dCas9 knock-in mice

Abstract CRISPR/dCas9 is a versatile tool that can be used to recruit various effectors and fluorescent molecules to defined genome regions where it can modulate genetic and epigenetic markers, or track the chromatin dynamics in live cells. In vivo applications of CRISPR/dCas9 in animals have been c...

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Bibliographic Details
Main Authors: Jinzhi Duan, Guangqing Lu, Yu Hong, Qingtao Hu, Xueying Mai, Jing Guo, Xiaofang Si, Fengchao Wang, Yu Zhang
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Genome Biology
Subjects:
CRISPR/dCas9
dCas9-EGFP
Knock-in mice
Genome labeling
Live imaging
Hepatocytes
Online Access:http://link.springer.com/article/10.1186/s13059-018-1530-1

Internet

http://link.springer.com/article/10.1186/s13059-018-1530-1

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