Functional abnormalities in first-episode major depressive disorder with somatic pain
Objective: Depression has a high incidence of somatic pain, and the mechanism of pain in depressed patients remains unclear. Our study explored brain areas with abnormal activity in first-episode major depressive disorder with somatic pain using resting-state functional magnetic resonance imaging (r...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-12-01
|
Series: | Journal of Affective Disorders Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915320300299 |
id |
doaj-3ddcc19b476a465dbce1f5ab9fcdf9f7 |
---|---|
record_format |
Article |
spelling |
doaj-3ddcc19b476a465dbce1f5ab9fcdf9f72021-02-27T04:41:49ZengElsevierJournal of Affective Disorders Reports2666-91532020-12-012100029Functional abnormalities in first-episode major depressive disorder with somatic painJiaquan Liang0Hairong Liao1Xiaoling Li2Caixia Xu3Zhenyu Xu4Yang Yu5Hui Zhou6Xiaobing Lu7Guojun Xie8The Third People's Hospital of Foshan, Guangdong 528000, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangdong 510000, ChinaThe Third People's Hospital of Foshan, Guangdong 528000, ChinaThe Third People's Hospital of Foshan, Guangdong 528000, ChinaThe Third People's Hospital of Foshan, Guangdong 528000, ChinaAffiliated Brain Hospital of Guangzhou Medical University, Guangdong 510000, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangdong 510000, ChinaThe Third People's Hospital of Foshan, Guangdong 528000, ChinaThe Third People's Hospital of Foshan, Guangdong 528000, ChinaAffiliated Brain Hospital of Guangzhou Medical University, Guangdong 510000, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangdong 510000, China; Corresponding authors at: The Third People's Hospital of Foshan, Guangdong 528000, China; Affiliated Hospital of Guangzhou Medical University, Guangdong 510000, China.The Third People's Hospital of Foshan, Guangdong 528000, China; Corresponding authors at: The Third People's Hospital of Foshan, Guangdong 528000, China; Affiliated Hospital of Guangzhou Medical University, Guangdong 510000, China.Objective: Depression has a high incidence of somatic pain, and the mechanism of pain in depressed patients remains unclear. Our study explored brain areas with abnormal activity in first-episode major depressive disorder with somatic pain using resting-state functional magnetic resonance imaging (rfMRI) and the relationship between depression and somatic pain. Methods: Thirty-two depressed patients (sixteen with somatic pain and sixteen without somatic pain) diagnosed with major depressive disorder by the Structured Clinical Interview for DSM-IV and thirty-three healthy controls were scanned by rfMRI. Regional homogeneity (ReHo) was used to analyze differences between depressed patients with somatic pain and those without somatic pain. Results: ReHo values in the left postcentral gyrus (postcentral_l) and the left precentral gyrus (precentral_l) of the depressed patients with somatic pain were significantly higher than those in the patients without somatic pain (tpostcentral_l = 4.93, ppostcentral_l<0.001; tprecentral_l = 4.57, pprecentral_l<0.001), and the ReHo values in both areas were positively correlated with the pain scores (rpostcentral_l = 0.511, ppostcentral_l<0.001; rprecentral_l = 0.466, pprecentral_l <0.001). Conclusions: Abnormalities in the left postcentral gyrus and precentral gyrus (sensorimotor area) may play important roles in depressed patients with somatic pain.http://www.sciencedirect.com/science/article/pii/S2666915320300299Depression with somatic painMajor depressive disorderPainFunctional magnetic resonance imagingRegional homogeneity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiaquan Liang Hairong Liao Xiaoling Li Caixia Xu Zhenyu Xu Yang Yu Hui Zhou Xiaobing Lu Guojun Xie |
spellingShingle |
Jiaquan Liang Hairong Liao Xiaoling Li Caixia Xu Zhenyu Xu Yang Yu Hui Zhou Xiaobing Lu Guojun Xie Functional abnormalities in first-episode major depressive disorder with somatic pain Journal of Affective Disorders Reports Depression with somatic pain Major depressive disorder Pain Functional magnetic resonance imaging Regional homogeneity |
author_facet |
Jiaquan Liang Hairong Liao Xiaoling Li Caixia Xu Zhenyu Xu Yang Yu Hui Zhou Xiaobing Lu Guojun Xie |
author_sort |
Jiaquan Liang |
title |
Functional abnormalities in first-episode major depressive disorder with somatic pain |
title_short |
Functional abnormalities in first-episode major depressive disorder with somatic pain |
title_full |
Functional abnormalities in first-episode major depressive disorder with somatic pain |
title_fullStr |
Functional abnormalities in first-episode major depressive disorder with somatic pain |
title_full_unstemmed |
Functional abnormalities in first-episode major depressive disorder with somatic pain |
title_sort |
functional abnormalities in first-episode major depressive disorder with somatic pain |
publisher |
Elsevier |
series |
Journal of Affective Disorders Reports |
issn |
2666-9153 |
publishDate |
2020-12-01 |
description |
Objective: Depression has a high incidence of somatic pain, and the mechanism of pain in depressed patients remains unclear. Our study explored brain areas with abnormal activity in first-episode major depressive disorder with somatic pain using resting-state functional magnetic resonance imaging (rfMRI) and the relationship between depression and somatic pain. Methods: Thirty-two depressed patients (sixteen with somatic pain and sixteen without somatic pain) diagnosed with major depressive disorder by the Structured Clinical Interview for DSM-IV and thirty-three healthy controls were scanned by rfMRI. Regional homogeneity (ReHo) was used to analyze differences between depressed patients with somatic pain and those without somatic pain. Results: ReHo values in the left postcentral gyrus (postcentral_l) and the left precentral gyrus (precentral_l) of the depressed patients with somatic pain were significantly higher than those in the patients without somatic pain (tpostcentral_l = 4.93, ppostcentral_l<0.001; tprecentral_l = 4.57, pprecentral_l<0.001), and the ReHo values in both areas were positively correlated with the pain scores (rpostcentral_l = 0.511, ppostcentral_l<0.001; rprecentral_l = 0.466, pprecentral_l <0.001). Conclusions: Abnormalities in the left postcentral gyrus and precentral gyrus (sensorimotor area) may play important roles in depressed patients with somatic pain. |
topic |
Depression with somatic pain Major depressive disorder Pain Functional magnetic resonance imaging Regional homogeneity |
url |
http://www.sciencedirect.com/science/article/pii/S2666915320300299 |
work_keys_str_mv |
AT jiaquanliang functionalabnormalitiesinfirstepisodemajordepressivedisorderwithsomaticpain AT hairongliao functionalabnormalitiesinfirstepisodemajordepressivedisorderwithsomaticpain AT xiaolingli functionalabnormalitiesinfirstepisodemajordepressivedisorderwithsomaticpain AT caixiaxu functionalabnormalitiesinfirstepisodemajordepressivedisorderwithsomaticpain AT zhenyuxu functionalabnormalitiesinfirstepisodemajordepressivedisorderwithsomaticpain AT yangyu functionalabnormalitiesinfirstepisodemajordepressivedisorderwithsomaticpain AT huizhou functionalabnormalitiesinfirstepisodemajordepressivedisorderwithsomaticpain AT xiaobinglu functionalabnormalitiesinfirstepisodemajordepressivedisorderwithsomaticpain AT guojunxie functionalabnormalitiesinfirstepisodemajordepressivedisorderwithsomaticpain |
_version_ |
1724248245896478720 |