Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of a TcdB–CSPG4 complex and CDI mouse models offer insights into CSPG4 role in CDIs and suggest a therapeutic strategy targeting TcdB....

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Main Authors: Peng Chen, Ji Zeng, Zheng Liu, Hatim Thaker, Siyu Wang, Songhai Tian, Jie Zhang, Liang Tao, Craig B. Gutierrez, Li Xing, Ralf Gerhard, Lan Huang, Min Dong, Rongsheng Jin
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23878-3
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spelling doaj-3de58ad2a56840ca9197090b475a1c572021-06-20T11:11:25ZengNature Publishing GroupNature Communications2041-17232021-06-0112111310.1038/s41467-021-23878-3Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infectionPeng Chen0Ji Zeng1Zheng Liu2Hatim Thaker3Siyu Wang4Songhai Tian5Jie Zhang6Liang Tao7Craig B. Gutierrez8Li Xing9Ralf Gerhard10Lan Huang11Min Dong12Rongsheng Jin13Department of Physiology and Biophysics, University of CaliforniaDepartment of Urology, Boston Children’s Hospital, Harvard Medical SchoolDepartment of Physiology and Biophysics, University of CaliforniaDepartment of Urology, Boston Children’s Hospital, Harvard Medical SchoolDepartment of Urology, Boston Children’s Hospital, Harvard Medical SchoolDepartment of Urology, Boston Children’s Hospital, Harvard Medical SchoolDepartment of Urology, Boston Children’s Hospital, Harvard Medical SchoolCenter for Infectious Disease Research, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityDepartment of Physiology and Biophysics, University of CaliforniaUC Irvine Materials Research Institute (IMRI), University of CaliforniaInstitute of Toxicology, Hannover Medical SchoolDepartment of Physiology and Biophysics, University of CaliforniaDepartment of Urology, Boston Children’s Hospital, Harvard Medical SchoolDepartment of Physiology and Biophysics, University of CaliforniaChondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of a TcdB–CSPG4 complex and CDI mouse models offer insights into CSPG4 role in CDIs and suggest a therapeutic strategy targeting TcdB.https://doi.org/10.1038/s41467-021-23878-3
collection DOAJ
language English
format Article
sources DOAJ
author Peng Chen
Ji Zeng
Zheng Liu
Hatim Thaker
Siyu Wang
Songhai Tian
Jie Zhang
Liang Tao
Craig B. Gutierrez
Li Xing
Ralf Gerhard
Lan Huang
Min Dong
Rongsheng Jin
spellingShingle Peng Chen
Ji Zeng
Zheng Liu
Hatim Thaker
Siyu Wang
Songhai Tian
Jie Zhang
Liang Tao
Craig B. Gutierrez
Li Xing
Ralf Gerhard
Lan Huang
Min Dong
Rongsheng Jin
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
Nature Communications
author_facet Peng Chen
Ji Zeng
Zheng Liu
Hatim Thaker
Siyu Wang
Songhai Tian
Jie Zhang
Liang Tao
Craig B. Gutierrez
Li Xing
Ralf Gerhard
Lan Huang
Min Dong
Rongsheng Jin
author_sort Peng Chen
title Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
title_short Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
title_full Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
title_fullStr Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
title_full_unstemmed Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
title_sort structural basis for cspg4 as a receptor for tcdb and a therapeutic target in clostridioides difficile infection
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of a TcdB–CSPG4 complex and CDI mouse models offer insights into CSPG4 role in CDIs and suggest a therapeutic strategy targeting TcdB.
url https://doi.org/10.1038/s41467-021-23878-3
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