Morphological and phenotypic markers of connective tissue dysplasia patients with varicose veins lower limb

• Main Author: E. A. Zaharyan
• Format: Article
• Language: English
• Published: Zaporozhye State Medical University 2013-02-01
• Series: Zaporožskij Medicinskij Žurnal
• Subjects: connective tissue dysplasia; phenotypical and morcal features; varicose disease of the veins of the lower extremities
• Online Access: http://zmj.zsmu.edu.ua/article/view/15446/13292

The features of structure of the vein and integuments are found in the patients with undifferentiated СТD at histological and immunohistochemical study in comparison with the group with a minimum number of stigma: an hypotrophy of smooth-muscle fibers of the veins of the lower extremities; areas of a hypertrophy of the endothelial and subendothelial layers of the vein; deformation and sclerosis of the wall of vein; intensifying of an expression of collagen I type or reduction of III type; dystrophia of epidermis of the skin; deformation of collagen in derma on a background of a hypertrophy of areas of a stratum granulosum; disturbance of a vascular permeability; a perivascular lymphocytic infiltration in derma. It is confirmed, that detailed phenotypical features of severe connective-tissue dysplasia on frequency of occurrence and peculiarities coincide with morphological and immunohistochemical stigma of connective tissue dysplasia, describing severity of the disease, a resistance to therapy of trophic ulcers, frequency of relapses of disease of veins. It can have prognostic value and determine the intensity of therapy and as a whole therapeutic approach.