Quantitative Analysis of Abdominal Aortic Calcification in CKD Patients Without Dialysis Therapy by Use of the Agatston Score

• Main Authors: Mitsuru Ichii, Eiji Ishimura, Hideaki Shima, Yoshiteru Ohno, Akinobu Ochi, Shinya Nakatani, Akihiro Tsuda, Shoichi Ehara, Katsuhito Mori, Shinya Fukumoto, Toshihide Naganuma, Yoshiaki Takemoto, Tatsuya Nakatani, Masaaki Inaba
• Format: Article
• Language: English
• Published: Karger Publishers 2014-04-01
• Series: Kidney & Blood Pressure Research
• Subjects: Agatston score; Aortic calcification; Chronic kidney disease; Multi-slice computed tomography
• Online Access: http://www.karger.com/Article/FullText/355768
• ISSN: 1420-4096; 1423-0143

Background/Aim: The aim of the present study was to quantitatively examine factors associated with aortic calcification in non-dialysis CKD patients. Methods: We quantitatively investigated aortic calcification from the renal artery to the bifurcation in 149 non-dialysis CKD patients (58±16 years; 96 males and 53 females, 48 diabetics; eGFR 40.3±29.3 ml/min), and measured Agatston scores using multi-slice computed tomography. Result: Of 149 patients, aortic calcification was present in 117. In patients with aortic calcification, age (pConclusions: Hyperphospatemia, chronic inflammation, diabetes, and decreased GFR are associated significantly with the presence of aortic calcification in non-dialysis CKD patients. Decreased eGFR was associated significantly and independently with the quantitative degree of aortic calcification.