Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat
A biodegradable sponge, composed of chitosan (CS) and sodium alginate (SA), was successfully obtained in this work. The sponge was ethereal and pliable. The chemical structure and morphology of the sponges was characterized by FTIR and SEM. The swelling ability, in vitro drug release and degradation...
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doaj-3def14e56b1e4294a78fbcedc9ea0c8f2020-11-25T00:50:44ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512009-01-01200910.1155/2009/595126595126Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in RatMei Dai0XiuLing Zheng1Xu Xu2XiangYe Kong3XingYi Li4Gang Guo5Feng Luo6Xia Zhao7Yu Quan Wei8Zhiyong Qian9State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, ChinaA biodegradable sponge, composed of chitosan (CS) and sodium alginate (SA), was successfully obtained in this work. The sponge was ethereal and pliable. The chemical structure and morphology of the sponges was characterized by FTIR and SEM. The swelling ability, in vitro drug release and degradation behaviors, and an in vivo animal test were employed to confirm the applicability of this sponge as a wound dressing material. As the chitosan content in the sponge decreased, the swelling ability decreased. All types of the sponges exhibited biodegradable properties. The release of curcumin from the sponges could be controlled by the crosslinking degree. Curcumin could be released from the sponges in an extended period for up to 20 days. An in vivo animal test using SD rat showed that sponge had better effect than cotton gauze, and adding curcumin into the sponge enhanced the therapeutic healing effect.http://dx.doi.org/10.1155/2009/595126 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mei Dai XiuLing Zheng Xu Xu XiangYe Kong XingYi Li Gang Guo Feng Luo Xia Zhao Yu Quan Wei Zhiyong Qian |
spellingShingle |
Mei Dai XiuLing Zheng Xu Xu XiangYe Kong XingYi Li Gang Guo Feng Luo Xia Zhao Yu Quan Wei Zhiyong Qian Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat Journal of Biomedicine and Biotechnology |
author_facet |
Mei Dai XiuLing Zheng Xu Xu XiangYe Kong XingYi Li Gang Guo Feng Luo Xia Zhao Yu Quan Wei Zhiyong Qian |
author_sort |
Mei Dai |
title |
Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat |
title_short |
Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat |
title_full |
Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat |
title_fullStr |
Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat |
title_full_unstemmed |
Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat |
title_sort |
chitosan-alginate sponge: preparation and application in curcumin delivery for dermal wound healing in rat |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2009-01-01 |
description |
A biodegradable sponge, composed of chitosan (CS) and sodium alginate (SA), was successfully obtained in this work. The sponge was ethereal and pliable. The chemical structure and morphology of the sponges was characterized by FTIR and SEM. The swelling ability, in vitro drug release and degradation behaviors, and an in vivo animal test were employed to confirm the applicability of this sponge as a wound dressing material. As the chitosan content in the sponge decreased, the swelling ability decreased. All types of the sponges exhibited biodegradable properties. The release of curcumin from the sponges could be controlled by the crosslinking degree. Curcumin could be released from the sponges in an extended period for up to 20 days. An in vivo animal test using SD rat showed that sponge had better effect than cotton gauze, and adding curcumin into the sponge enhanced the therapeutic healing effect. |
url |
http://dx.doi.org/10.1155/2009/595126 |
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