Identifying brain imaging correlates of clinical response to repetitive transcranial magnetic stimulation (rTMS) in major depression
Background: Partial response and non-response to treatments are common problems in major depression. The identification of biological markers of clinical response may be of special interest for some adjunctive treatments, such as repetitive transcranial magnetic stimulation (rTMS), as it may ultimat...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2013-01-01
|
Series: | Brain Stimulation |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X12000022 |
id |
doaj-3e110188c5a24a04b189342dc4dd49d2 |
---|---|
record_format |
Article |
spelling |
doaj-3e110188c5a24a04b189342dc4dd49d22021-03-18T04:35:43ZengElsevierBrain Stimulation1935-861X2013-01-01615461Identifying brain imaging correlates of clinical response to repetitive transcranial magnetic stimulation (rTMS) in major depressionRosa Hernández-Ribas0Joan Deus1Jesús Pujol2Cinto Segalàs3Julio Vallejo4José M. Menchón5Narcís Cardoner6Carles Soriano-Mas7Department of Psychiatry, Bellvitge University Hospital – IDIBELL, Barcelona, Spain; Carlos III Health Institute, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), SpainDepartment of Clinical and Health Psychology, Autonomous University of Barcelona, Barcelona, Spain; CRC Hospital del Mar, Barcelona, SpainCRC Hospital del Mar, Barcelona, SpainDepartment of Psychiatry, Bellvitge University Hospital – IDIBELL, Barcelona, Spain; Carlos III Health Institute, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), SpainDepartment of Psychiatry, Bellvitge University Hospital – IDIBELL, Barcelona, Spain; Carlos III Health Institute, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, SpainDepartment of Psychiatry, Bellvitge University Hospital – IDIBELL, Barcelona, Spain; Carlos III Health Institute, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, SpainDepartment of Psychiatry, Bellvitge University Hospital – IDIBELL, Barcelona, Spain; Carlos III Health Institute, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain; Corresponding author. Tel.: +34 932607500x2839; fax: +34 932607658.Department of Psychiatry, Bellvitge University Hospital – IDIBELL, Barcelona, Spain; Carlos III Health Institute, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Corresponding author. Tel.: +34 932607500x2864; fax: +34 932607658.Background: Partial response and non-response to treatments are common problems in major depression. The identification of biological markers of clinical response may be of special interest for some adjunctive treatments, such as repetitive transcranial magnetic stimulation (rTMS), as it may ultimately improve their cost-effectiveness. Objective: To identify pre-treatment functional imaging correlates of clinical response to rTMS in major depression. Methods: We evaluated 21 depressed patients. They were randomized to receive 15 sessions of active or sham rTMS on the left dorsolateral prefrontal cortex. Functional magnetic resonance imaging (fMRI) was used to assess pre-treatment regional brain activity evoked by a word generation task. These regional activations were correlated (voxel-wise) with the Hamilton Rating Scale for Depression (HAM-D) reduction between baseline and end of treatment. A group of 13 healthy controls was also assessed using the same fMRI protocol to obtain reference imaging measurements. Results: At the end of treatment, the percentage of patients with a HAM-D reduction greater than 50% was larger in the active than in the sham rTMS group (70% vs. 27.3%). In the active rTMS group, larger HAM-D reductions were significantly correlated with smaller deactivations during pre-treatment fMRI assessment in the anterior cingulate, the left medial orbitofrontal and the right middle frontal cortices, in addition to larger activations in the left ventral-caudal putamen. Conclusions: These results suggest that brain activity in regions arguably relevant for major depression may predict clinical response to rTMS. This approach may help in identifying the most suitable candidates to undergo rTMS treatment.http://www.sciencedirect.com/science/article/pii/S1935861X12000022Repetitive transacranial magnetic stimulationFunctional magnetic resonance imagingDepressionCorrelates of treatment response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosa Hernández-Ribas Joan Deus Jesús Pujol Cinto Segalàs Julio Vallejo José M. Menchón Narcís Cardoner Carles Soriano-Mas |
spellingShingle |
Rosa Hernández-Ribas Joan Deus Jesús Pujol Cinto Segalàs Julio Vallejo José M. Menchón Narcís Cardoner Carles Soriano-Mas Identifying brain imaging correlates of clinical response to repetitive transcranial magnetic stimulation (rTMS) in major depression Brain Stimulation Repetitive transacranial magnetic stimulation Functional magnetic resonance imaging Depression Correlates of treatment response |
author_facet |
Rosa Hernández-Ribas Joan Deus Jesús Pujol Cinto Segalàs Julio Vallejo José M. Menchón Narcís Cardoner Carles Soriano-Mas |
author_sort |
Rosa Hernández-Ribas |
title |
Identifying brain imaging correlates of clinical response to repetitive transcranial magnetic stimulation (rTMS) in major depression |
title_short |
Identifying brain imaging correlates of clinical response to repetitive transcranial magnetic stimulation (rTMS) in major depression |
title_full |
Identifying brain imaging correlates of clinical response to repetitive transcranial magnetic stimulation (rTMS) in major depression |
title_fullStr |
Identifying brain imaging correlates of clinical response to repetitive transcranial magnetic stimulation (rTMS) in major depression |
title_full_unstemmed |
Identifying brain imaging correlates of clinical response to repetitive transcranial magnetic stimulation (rTMS) in major depression |
title_sort |
identifying brain imaging correlates of clinical response to repetitive transcranial magnetic stimulation (rtms) in major depression |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2013-01-01 |
description |
Background: Partial response and non-response to treatments are common problems in major depression. The identification of biological markers of clinical response may be of special interest for some adjunctive treatments, such as repetitive transcranial magnetic stimulation (rTMS), as it may ultimately improve their cost-effectiveness. Objective: To identify pre-treatment functional imaging correlates of clinical response to rTMS in major depression. Methods: We evaluated 21 depressed patients. They were randomized to receive 15 sessions of active or sham rTMS on the left dorsolateral prefrontal cortex. Functional magnetic resonance imaging (fMRI) was used to assess pre-treatment regional brain activity evoked by a word generation task. These regional activations were correlated (voxel-wise) with the Hamilton Rating Scale for Depression (HAM-D) reduction between baseline and end of treatment. A group of 13 healthy controls was also assessed using the same fMRI protocol to obtain reference imaging measurements. Results: At the end of treatment, the percentage of patients with a HAM-D reduction greater than 50% was larger in the active than in the sham rTMS group (70% vs. 27.3%). In the active rTMS group, larger HAM-D reductions were significantly correlated with smaller deactivations during pre-treatment fMRI assessment in the anterior cingulate, the left medial orbitofrontal and the right middle frontal cortices, in addition to larger activations in the left ventral-caudal putamen. Conclusions: These results suggest that brain activity in regions arguably relevant for major depression may predict clinical response to rTMS. This approach may help in identifying the most suitable candidates to undergo rTMS treatment. |
topic |
Repetitive transacranial magnetic stimulation Functional magnetic resonance imaging Depression Correlates of treatment response |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X12000022 |
work_keys_str_mv |
AT rosahernandezribas identifyingbrainimagingcorrelatesofclinicalresponsetorepetitivetranscranialmagneticstimulationrtmsinmajordepression AT joandeus identifyingbrainimagingcorrelatesofclinicalresponsetorepetitivetranscranialmagneticstimulationrtmsinmajordepression AT jesuspujol identifyingbrainimagingcorrelatesofclinicalresponsetorepetitivetranscranialmagneticstimulationrtmsinmajordepression AT cintosegalas identifyingbrainimagingcorrelatesofclinicalresponsetorepetitivetranscranialmagneticstimulationrtmsinmajordepression AT juliovallejo identifyingbrainimagingcorrelatesofclinicalresponsetorepetitivetranscranialmagneticstimulationrtmsinmajordepression AT josemmenchon identifyingbrainimagingcorrelatesofclinicalresponsetorepetitivetranscranialmagneticstimulationrtmsinmajordepression AT narciscardoner identifyingbrainimagingcorrelatesofclinicalresponsetorepetitivetranscranialmagneticstimulationrtmsinmajordepression AT carlessorianomas identifyingbrainimagingcorrelatesofclinicalresponsetorepetitivetranscranialmagneticstimulationrtmsinmajordepression |
_version_ |
1724217488344875008 |