Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation

Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation

Background: Status epilepticus (SE) is a neurological disorder characterized by a prolonged epileptic activity followed by subsequent epileptogenic processes. The aim of the present study was to evaluate the early effects of topiramate (TPM) and lacosamide (LCM) treatment on oxidative stress and inf...

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Bibliographic Details
Main Authors: Michaela Shishmanova-Doseva, Lyudmil Peychev, Lyubka Yoanidu, Yordanka Uzunova, Milena Atanasova, Katerina Georgieva, Jana Tchekalarova
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
status epilepticus
anticonvulsants
oxidative stress
IL-1β
TNF-α
hippocampus
Online Access:https://www.mdpi.com/1422-0067/22/5/2264

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