Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration?
There is increasing evidence that a low vitamin D status may be an important and hitherto neglected factor of cardiovascular disease. This review is an overview of the current body of literature, and presents evidence of the mechanisms through which vitamin D deficiency affects the cardiovascular sy...
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Saudi Heart Association
2015-10-01
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doaj-3e1378b8acf34e5db6f1977e97f48e552020-11-25T04:03:52ZengSaudi Heart AssociationJournal of the Saudi Heart Association1016-73152015-10-0127426427110.1016/j.jsha.2015.02.003Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration?Zaher Fanari0Sumaya Hammami1Muhammad Baraa Hammami2Safa Hammami3Abdul Abdellatif4Section of Cardiology, Christiana Care Health System, Newark, DE, USASection of Cardiology, Christiana Care Health System, Newark, DE, USASection of Cardiology, Christiana Care Health System, Newark, DE, USASection of Cardiology, Christiana Care Health System, Newark, DE, USADepartment of Medicine, Division of Nephrology, Baylor College of Medicine, Houston, TX, USAThere is increasing evidence that a low vitamin D status may be an important and hitherto neglected factor of cardiovascular disease. This review is an overview of the current body of literature, and presents evidence of the mechanisms through which vitamin D deficiency affects the cardiovascular system in general and the heart in particular. Available data indicate that the majority of congestive heart failure patients have 25-hydroxyvitamin D deficiency. Furthermore, the low serum 25-hydroxyvitamin D level has a higher impact on hypertension, coronary artery disease an on the occurrence of relevant cardiac events. A serum 25-hydroxyvitamin D level below 75 nmol/l (30 ng/l) is generally regarded as vitamin D insufficiency in both adults and children, while a level below 50 nmol/l (20 ng/l) is considered deficiency. Levels below 50 nmol/l (20 ng/l) are linked independently to cardiovascular morbidity and mortality.http://www.sciencedirect.com/science/article/pii/S1016731515000044Vitamin D deficiencyCongestive heart failureCoronary artery diseaseCardiovascular outcomes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zaher Fanari Sumaya Hammami Muhammad Baraa Hammami Safa Hammami Abdul Abdellatif |
spellingShingle |
Zaher Fanari Sumaya Hammami Muhammad Baraa Hammami Safa Hammami Abdul Abdellatif Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration? Journal of the Saudi Heart Association Vitamin D deficiency Congestive heart failure Coronary artery disease Cardiovascular outcomes |
author_facet |
Zaher Fanari Sumaya Hammami Muhammad Baraa Hammami Safa Hammami Abdul Abdellatif |
author_sort |
Zaher Fanari |
title |
Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration? |
title_short |
Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration? |
title_full |
Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration? |
title_fullStr |
Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration? |
title_full_unstemmed |
Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration? |
title_sort |
vitamin d deficiency plays an important role in cardiac disease and affects patient outcome: still a myth or a fact that needs exploration? |
publisher |
Saudi Heart Association |
series |
Journal of the Saudi Heart Association |
issn |
1016-7315 |
publishDate |
2015-10-01 |
description |
There is increasing evidence that a low vitamin D status may be an important and hitherto neglected factor of cardiovascular disease. This review is an overview of the current body of literature, and presents evidence of the mechanisms through which vitamin D deficiency affects the cardiovascular system in general and the heart in particular. Available data indicate that the majority of congestive heart failure patients have 25-hydroxyvitamin D deficiency. Furthermore, the low serum 25-hydroxyvitamin D level has a higher impact on hypertension, coronary artery disease an on the occurrence of relevant cardiac events. A serum 25-hydroxyvitamin D level below 75 nmol/l (30 ng/l) is generally regarded as vitamin D insufficiency in both adults and children, while a level below 50 nmol/l (20 ng/l) is considered deficiency. Levels below 50 nmol/l (20 ng/l) are linked independently to cardiovascular morbidity and mortality. |
topic |
Vitamin D deficiency Congestive heart failure Coronary artery disease Cardiovascular outcomes |
url |
http://www.sciencedirect.com/science/article/pii/S1016731515000044 |
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